Effect of transdermal estrogen dose regimen for endometrial preparation of frozen‐thawed embryo transfer on reproductive and obstetric outcomes
Abstract Purpose Previous studies have reported different methods of estrogen administration during endometrial preparation for frozen‐thawed embryo transfer (FET). This study aimed to investigate a beneficial regimen of transdermal estrogen administration for FET. Methods We investigated the reprod...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-04-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12370 |
| _version_ | 1818727953511481344 |
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| author | Tatsuyuki Ogawa Tsuyoshi Kasai Maki Ogi Jiro Fukushima Shuji Hirata |
| author_facet | Tatsuyuki Ogawa Tsuyoshi Kasai Maki Ogi Jiro Fukushima Shuji Hirata |
| author_sort | Tatsuyuki Ogawa |
| collection | DOAJ |
| description | Abstract Purpose Previous studies have reported different methods of estrogen administration during endometrial preparation for frozen‐thawed embryo transfer (FET). This study aimed to investigate a beneficial regimen of transdermal estrogen administration for FET. Methods We investigated the reproductive and obstetric outcomes of FET by comparing the increasing dose (ID) group that mimics changes in serum estradiol during the menstrual cycle and the constant dose (CD) group. Transdermal patches were used for estrogen administration in both groups. In our hospital, we targeted 315 cycles of the ID group in which FET was performed in 2017 and 324 cycles of the CD group in which FET was performed in 2018. In all cases, single embryo transfer was performed. Results All were singleton pregnancies. There was no difference in clinical pregnancy rate (28.9% vs 28.2%, P =.837) and live birth rate (17.3% vs 21.4%, P =.201) between the ID and CD groups. Spontaneous abortion rate was significantly lower in the CD group than in the ID group (37.2% vs 23.0%, P =.041). There was no difference in obstetrical outcomes. Conclusions It was considered that the simple CD regimen may be more beneficial than the complicated ID regimen. |
| first_indexed | 2024-12-17T22:22:17Z |
| format | Article |
| id | doaj.art-66d4da1342c44fed8e23934c99162a5e |
| institution | Directory Open Access Journal |
| issn | 1445-5781 1447-0578 |
| language | English |
| last_indexed | 2024-12-17T22:22:17Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj.art-66d4da1342c44fed8e23934c99162a5e2022-12-21T21:30:27ZengWileyReproductive Medicine and Biology1445-57811447-05782021-04-0120220821410.1002/rmb2.12370Effect of transdermal estrogen dose regimen for endometrial preparation of frozen‐thawed embryo transfer on reproductive and obstetric outcomesTatsuyuki Ogawa0Tsuyoshi Kasai1Maki Ogi2Jiro Fukushima3Shuji Hirata4Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi Chuo JapanDepartment of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi Chuo JapanDepartment of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi Chuo JapanDepartment of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi Chuo JapanDepartment of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi Chuo JapanAbstract Purpose Previous studies have reported different methods of estrogen administration during endometrial preparation for frozen‐thawed embryo transfer (FET). This study aimed to investigate a beneficial regimen of transdermal estrogen administration for FET. Methods We investigated the reproductive and obstetric outcomes of FET by comparing the increasing dose (ID) group that mimics changes in serum estradiol during the menstrual cycle and the constant dose (CD) group. Transdermal patches were used for estrogen administration in both groups. In our hospital, we targeted 315 cycles of the ID group in which FET was performed in 2017 and 324 cycles of the CD group in which FET was performed in 2018. In all cases, single embryo transfer was performed. Results All were singleton pregnancies. There was no difference in clinical pregnancy rate (28.9% vs 28.2%, P =.837) and live birth rate (17.3% vs 21.4%, P =.201) between the ID and CD groups. Spontaneous abortion rate was significantly lower in the CD group than in the ID group (37.2% vs 23.0%, P =.041). There was no difference in obstetrical outcomes. Conclusions It was considered that the simple CD regimen may be more beneficial than the complicated ID regimen.https://doi.org/10.1002/rmb2.12370constant doseendometrial preparationfrozen‐thawed embryo transferhormone replacement cycletransdermal estrogen patches |
| spellingShingle | Tatsuyuki Ogawa Tsuyoshi Kasai Maki Ogi Jiro Fukushima Shuji Hirata Effect of transdermal estrogen dose regimen for endometrial preparation of frozen‐thawed embryo transfer on reproductive and obstetric outcomes Reproductive Medicine and Biology constant dose endometrial preparation frozen‐thawed embryo transfer hormone replacement cycle transdermal estrogen patches |
| title | Effect of transdermal estrogen dose regimen for endometrial preparation of frozen‐thawed embryo transfer on reproductive and obstetric outcomes |
| title_full | Effect of transdermal estrogen dose regimen for endometrial preparation of frozen‐thawed embryo transfer on reproductive and obstetric outcomes |
| title_fullStr | Effect of transdermal estrogen dose regimen for endometrial preparation of frozen‐thawed embryo transfer on reproductive and obstetric outcomes |
| title_full_unstemmed | Effect of transdermal estrogen dose regimen for endometrial preparation of frozen‐thawed embryo transfer on reproductive and obstetric outcomes |
| title_short | Effect of transdermal estrogen dose regimen for endometrial preparation of frozen‐thawed embryo transfer on reproductive and obstetric outcomes |
| title_sort | effect of transdermal estrogen dose regimen for endometrial preparation of frozen thawed embryo transfer on reproductive and obstetric outcomes |
| topic | constant dose endometrial preparation frozen‐thawed embryo transfer hormone replacement cycle transdermal estrogen patches |
| url | https://doi.org/10.1002/rmb2.12370 |
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