Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study
ObjectiveOur knowledge on the long-term consequences of COVID-19 is still scarce despite the clinical relevance of persisting syndrome. The aim of this study was to analyze patient-reported outcomes, including assessment by specific questionnaires of health impairment and symptoms.MethodsThis is a p...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.834354/full |
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| author | Agnese Comelli Giulia Viero Greta Bettini Alessandro Nobili Mauro Tettamanti Alessia Antonella Galbussera Antonio Muscatello Marco Mantero Marco Mantero Ciro Canetta Filippo Martinelli Boneschi Filippo Martinelli Boneschi Filippo Martinelli Boneschi Andrea Arighi Paolo Brambilla Paolo Brambilla Maurizio Vecchi Maurizio Vecchi Pietro Lampertico Pietro Lampertico Paolo Bonfanti Marco Contoli Francesco Blasi Francesco Blasi Andrea Gori Andrea Gori Alessandra Bandera Alessandra Bandera |
| author_facet | Agnese Comelli Giulia Viero Greta Bettini Alessandro Nobili Mauro Tettamanti Alessia Antonella Galbussera Antonio Muscatello Marco Mantero Marco Mantero Ciro Canetta Filippo Martinelli Boneschi Filippo Martinelli Boneschi Filippo Martinelli Boneschi Andrea Arighi Paolo Brambilla Paolo Brambilla Maurizio Vecchi Maurizio Vecchi Pietro Lampertico Pietro Lampertico Paolo Bonfanti Marco Contoli Francesco Blasi Francesco Blasi Andrea Gori Andrea Gori Alessandra Bandera Alessandra Bandera |
| author_sort | Agnese Comelli |
| collection | DOAJ |
| description | ObjectiveOur knowledge on the long-term consequences of COVID-19 is still scarce despite the clinical relevance of persisting syndrome. The aim of this study was to analyze patient-reported outcomes, including assessment by specific questionnaires of health impairment and symptoms.MethodsThis is a prospective, observational and multicenter cohort study coordinated by Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico di Milano and Istituto di Ricerche Farmacologiche Mario Negri IRCCS including eight hospitals located in North and Central Italy. A telephone interview to assess rehospitalization, access to health care resources, general health status subjective evaluation, and symptoms was performed at 12 months after the discharge in patients admitted to hospital because of COVID-19 from February 2020 to the end of May 2020.ResultsAmong the 776 patients discharged alive, 44 (5.7%) died, 456 subjects (58.8%) completed the questionnaire and 276 (35.6%) were not reachable or refused to join the telephone interview. The mean age of the study population was 59.4 years (SD 14.1), 69.8% of individuals needed oxygen support during hospitalization and 10.4% were admitted to ICU. Overall, 91.7% of participants reported at least one symptom/sequela at 12 months. Exertional dyspnea (71.7%), fatigue (54.6%), and gastrointestinal symptoms (32.8%) were the most reported ones. Health issues after discharge including hospitalization or access to emergency room were described by 19.4% of subjects. Female and presence of comorbidities were independent predictors of whealth impairment and presence of ≥2 symptoms/sequelae after 12 months from hospitalization for COVID-19.ConclusionsPatient-reported symptoms and sequelae, principally dyspnea and fatigue, are found in most individuals even 12 months from COVID-19 hospitalization. Long-term follow-up based on patient-centered outcome can contribute to plan tailored interventions. |
| first_indexed | 2024-12-10T16:03:02Z |
| format | Article |
| id | doaj.art-66d51260f7044414b61f48eec94c68bb |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-10T16:03:02Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-66d51260f7044414b61f48eec94c68bb2022-12-22T01:42:20ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-03-01910.3389/fmed.2022.834354834354Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up StudyAgnese Comelli0Giulia Viero1Greta Bettini2Alessandro Nobili3Mauro Tettamanti4Alessia Antonella Galbussera5Antonio Muscatello6Marco Mantero7Marco Mantero8Ciro Canetta9Filippo Martinelli Boneschi10Filippo Martinelli Boneschi11Filippo Martinelli Boneschi12Andrea Arighi13Paolo Brambilla14Paolo Brambilla15Maurizio Vecchi16Maurizio Vecchi17Pietro Lampertico18Pietro Lampertico19Paolo Bonfanti20Marco Contoli21Francesco Blasi22Francesco Blasi23Andrea Gori24Andrea Gori25Alessandra Bandera26Alessandra Bandera27Infectious Diseases Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, Milan, ItalyDepartment of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, ItalyDepartment of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, ItalyDepartment of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, ItalyInfectious Diseases Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, Milan, ItalyRespiratory Unit and Cystic Fibrosis Adult Centre, Internal Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyAcute Medical Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, Milan, ItalyNeurology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Neurosciences and Mental Health, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyNeurology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, Milan, ItalyDepartment of Neurosciences and Mental Health, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, Milan, ItalyGastroenterology and Endoscopy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, Milan, ItalyCRC “A. M. and A. Migliavacca” Center for Liver Disease, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy0Infectious Diseases Unit, Azienda Socio Sanitaria Territoriale Monza, San Gerardo Hospital, Monza, Italy1Research Centre on Asthma and Chronic Obstructive Pulmonary Disease, Department of Medical Sciences, University of Ferrara, Ferrara, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, Milan, ItalyRespiratory Unit and Cystic Fibrosis Adult Centre, Internal Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyInfectious Diseases Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, Milan, ItalyInfectious Diseases Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, Milan, ItalyObjectiveOur knowledge on the long-term consequences of COVID-19 is still scarce despite the clinical relevance of persisting syndrome. The aim of this study was to analyze patient-reported outcomes, including assessment by specific questionnaires of health impairment and symptoms.MethodsThis is a prospective, observational and multicenter cohort study coordinated by Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico di Milano and Istituto di Ricerche Farmacologiche Mario Negri IRCCS including eight hospitals located in North and Central Italy. A telephone interview to assess rehospitalization, access to health care resources, general health status subjective evaluation, and symptoms was performed at 12 months after the discharge in patients admitted to hospital because of COVID-19 from February 2020 to the end of May 2020.ResultsAmong the 776 patients discharged alive, 44 (5.7%) died, 456 subjects (58.8%) completed the questionnaire and 276 (35.6%) were not reachable or refused to join the telephone interview. The mean age of the study population was 59.4 years (SD 14.1), 69.8% of individuals needed oxygen support during hospitalization and 10.4% were admitted to ICU. Overall, 91.7% of participants reported at least one symptom/sequela at 12 months. Exertional dyspnea (71.7%), fatigue (54.6%), and gastrointestinal symptoms (32.8%) were the most reported ones. Health issues after discharge including hospitalization or access to emergency room were described by 19.4% of subjects. Female and presence of comorbidities were independent predictors of whealth impairment and presence of ≥2 symptoms/sequelae after 12 months from hospitalization for COVID-19.ConclusionsPatient-reported symptoms and sequelae, principally dyspnea and fatigue, are found in most individuals even 12 months from COVID-19 hospitalization. Long-term follow-up based on patient-centered outcome can contribute to plan tailored interventions.https://www.frontiersin.org/articles/10.3389/fmed.2022.834354/fulllong COVID-19SARS-CoV-2long-term sequelaeCOVID-19dyspnea |
| spellingShingle | Agnese Comelli Giulia Viero Greta Bettini Alessandro Nobili Mauro Tettamanti Alessia Antonella Galbussera Antonio Muscatello Marco Mantero Marco Mantero Ciro Canetta Filippo Martinelli Boneschi Filippo Martinelli Boneschi Filippo Martinelli Boneschi Andrea Arighi Paolo Brambilla Paolo Brambilla Maurizio Vecchi Maurizio Vecchi Pietro Lampertico Pietro Lampertico Paolo Bonfanti Marco Contoli Francesco Blasi Francesco Blasi Andrea Gori Andrea Gori Alessandra Bandera Alessandra Bandera Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study Frontiers in Medicine long COVID-19 SARS-CoV-2 long-term sequelae COVID-19 dyspnea |
| title | Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study |
| title_full | Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study |
| title_fullStr | Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study |
| title_full_unstemmed | Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study |
| title_short | Patient-Reported Symptoms and Sequelae 12 Months After COVID-19 in Hospitalized Adults: A Multicenter Long-Term Follow-Up Study |
| title_sort | patient reported symptoms and sequelae 12 months after covid 19 in hospitalized adults a multicenter long term follow up study |
| topic | long COVID-19 SARS-CoV-2 long-term sequelae COVID-19 dyspnea |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.834354/full |
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