The prognostic value of peripheral arteries diseases in patients with ST-segment elevation myocardial infarction
Aims. To evaluate the clinical and prognostic role of hemodynamically insignificant stenosis of the extracranial arteries and lower extremity arteries in patients after myocardial infarction with ST – Seg ment elevation. Methods and results. The study sample consisted of 423 consecutively admi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2012-06-01
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| Series: | Атеросклероз |
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| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/637/574 |
| _version_ | 1797963430611648512 |
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| author | M. V. Zykov D. S. Zykova V. V. Kashtalap T. B. Pecherina O. L. Barbarash |
| author_facet | M. V. Zykov D. S. Zykova V. V. Kashtalap T. B. Pecherina O. L. Barbarash |
| author_sort | M. V. Zykov |
| collection | DOAJ |
| description | Aims. To evaluate the clinical and prognostic role of hemodynamically insignificant stenosis of the extracranial arteries and lower extremity arteries in patients after myocardial infarction with ST – Seg ment elevation.
Methods and results. The study sample consisted of 423 consecutively admitted patients in Kemerovo Cardiological Clinic with ST-Segment elevation myocardial infarction (STEMI). The disease outcome was defined in 397 patients (95.4 % of the initially discharged patients) a year later. 39 fatal outcomes were registered.
Results. The incidence of polyvascular diseases (PVD), defined by the intima-media thickness of the common carotid artery or presenting stenosis of any severity of the extracranial arteries (ECA) or lower extremity arteries (LEA) was substantially high – 95 %. The increasing severity degree of peripheral arteries stenosis was noted to raise significantly the cardiovascular risk factors incidence. In patients without PVD (n = 18) no fatal outcomes were registered, in patients with the ECA or LEA stenosis – >30 % (n = 193), the mortality rate was 5.7 %, and with stenosis < 30 % (n = 186) – 15,1 % (χ2 = 11,4, p = 0.003). Using the GRACE score model together with the additional factors determination (presenting congestive heart failure, PVD, prior stroke, smoking) enables to create a scheme (KemScore) of death risk stratification for 12-month period, with the value of the area under the ROC-curve 0.83 (0.76, 0.90), that is significantly higher than the initial GRACE score – 0.71 (0.63, 0.79).
Conclusion. Additional risk factors determination, including peripheral arterial stenosis of 30 % and more, enables to optimize the predictive GRACE score model value. |
| first_indexed | 2024-04-11T01:29:16Z |
| format | Article |
| id | doaj.art-66d5473034fb46d79ed2ae0c301194de |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T01:29:16Z |
| publishDate | 2012-06-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-66d5473034fb46d79ed2ae0c301194de2023-01-03T10:01:15ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2012-06-01811420The prognostic value of peripheral arteries diseases in patients with ST-segment elevation myocardial infarctionM. V. Zykov0D. S. Zykova1V. V. Kashtalap2T. B. Pecherina3O. L. Barbarash4Ministry of Health and Social Development of Russia Russian Federation State Budgetary Educational Institution of Higher Professional Education Kemerovo State Medical AcademyRAMS Russian Federation SB RAMS Federal State Budgetary Institution Research Institute of Complex Problems of Cardiovascular DiseasesRAMS Russian Federation SB RAMS Federal State Budgetary Institution Research Institute of Complex Problems of Cardiovascular DiseasesMinistry of Health and Social Development of Russia Russian Federation State Budgetary Educational Institution of Higher Professional Education Kemerovo State Medical AcademyRAMS Russian Federation SB RAMS Federal State Budgetary Institution Research Institute of Complex Problems of Cardiovascular DiseasesAims. To evaluate the clinical and prognostic role of hemodynamically insignificant stenosis of the extracranial arteries and lower extremity arteries in patients after myocardial infarction with ST – Seg ment elevation. Methods and results. The study sample consisted of 423 consecutively admitted patients in Kemerovo Cardiological Clinic with ST-Segment elevation myocardial infarction (STEMI). The disease outcome was defined in 397 patients (95.4 % of the initially discharged patients) a year later. 39 fatal outcomes were registered. Results. The incidence of polyvascular diseases (PVD), defined by the intima-media thickness of the common carotid artery or presenting stenosis of any severity of the extracranial arteries (ECA) or lower extremity arteries (LEA) was substantially high – 95 %. The increasing severity degree of peripheral arteries stenosis was noted to raise significantly the cardiovascular risk factors incidence. In patients without PVD (n = 18) no fatal outcomes were registered, in patients with the ECA or LEA stenosis – >30 % (n = 193), the mortality rate was 5.7 %, and with stenosis < 30 % (n = 186) – 15,1 % (χ2 = 11,4, p = 0.003). Using the GRACE score model together with the additional factors determination (presenting congestive heart failure, PVD, prior stroke, smoking) enables to create a scheme (KemScore) of death risk stratification for 12-month period, with the value of the area under the ROC-curve 0.83 (0.76, 0.90), that is significantly higher than the initial GRACE score – 0.71 (0.63, 0.79). Conclusion. Additional risk factors determination, including peripheral arterial stenosis of 30 % and more, enables to optimize the predictive GRACE score model value.https://ateroskleroz.elpub.ru/jour/article/view/637/574acute coronary syndromepolyvascular diseasesgrace score model |
| spellingShingle | M. V. Zykov D. S. Zykova V. V. Kashtalap T. B. Pecherina O. L. Barbarash The prognostic value of peripheral arteries diseases in patients with ST-segment elevation myocardial infarction Атеросклероз acute coronary syndrome polyvascular diseases grace score model |
| title | The prognostic value of peripheral arteries diseases in patients with ST-segment elevation myocardial infarction |
| title_full | The prognostic value of peripheral arteries diseases in patients with ST-segment elevation myocardial infarction |
| title_fullStr | The prognostic value of peripheral arteries diseases in patients with ST-segment elevation myocardial infarction |
| title_full_unstemmed | The prognostic value of peripheral arteries diseases in patients with ST-segment elevation myocardial infarction |
| title_short | The prognostic value of peripheral arteries diseases in patients with ST-segment elevation myocardial infarction |
| title_sort | prognostic value of peripheral arteries diseases in patients with st segment elevation myocardial infarction |
| topic | acute coronary syndrome polyvascular diseases grace score model |
| url | https://ateroskleroz.elpub.ru/jour/article/view/637/574 |
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