Microbes in the Era of Circadian Medicine
The organisms of most domains of life have adapted to circadian changes of the environment and regulate their behavior and physiology accordingly. A particular case of such paradigm is represented by some types of host-pathogen interaction during infection. Indeed, not only some hosts and pathogens...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-02-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.00030/full |
| _version_ | 1831683159746412544 |
|---|---|
| author | Claudio Costantini Giorgia Renga Federica Sellitto Monica Borghi Claudia Stincardini Marilena Pariano Teresa Zelante Flavia Chiarotti Andrea Bartoli Paolo Mosci Luigina Romani Stefano Brancorsini Marina Maria Bellet |
| author_facet | Claudio Costantini Giorgia Renga Federica Sellitto Monica Borghi Claudia Stincardini Marilena Pariano Teresa Zelante Flavia Chiarotti Andrea Bartoli Paolo Mosci Luigina Romani Stefano Brancorsini Marina Maria Bellet |
| author_sort | Claudio Costantini |
| collection | DOAJ |
| description | The organisms of most domains of life have adapted to circadian changes of the environment and regulate their behavior and physiology accordingly. A particular case of such paradigm is represented by some types of host-pathogen interaction during infection. Indeed, not only some hosts and pathogens are each endowed with their own circadian clock, but they are also influenced by the circadian changes of the other with profound consequences on the outcome of the infection. It comes that daily fluctuations in the availability of resources and the nature of the immune response, coupled with circadian changes of the pathogen, may influence microbial virulence, level of colonization and damage to the host, and alter the equilibrium between commensal and invading microorganisms. In the present review, we discuss the potential relevance of circadian rhythms in human bacterial and fungal pathogens, and the consequences of circadian changes of the host immune system and microbiome on the onset and development of infection. By looking from the perspective of the interplay between host and microbes circadian rhythms, these concepts are expected to change the way we approach human infections, not only by predicting the outcome of the host-pathogen interaction, but also by indicating the best time for intervention to potentiate the anti-microbial activities of the immune system and to weaken the pathogen when its susceptibility is higher. |
| first_indexed | 2024-12-20T06:32:33Z |
| format | Article |
| id | doaj.art-66d6018b84444557bf613f51bd573f2c |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-20T06:32:33Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-66d6018b84444557bf613f51bd573f2c2022-12-21T19:50:05ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-02-011010.3389/fcimb.2020.00030513487Microbes in the Era of Circadian MedicineClaudio Costantini0Giorgia Renga1Federica Sellitto2Monica Borghi3Claudia Stincardini4Marilena Pariano5Teresa Zelante6Flavia Chiarotti7Andrea Bartoli8Paolo Mosci9Luigina Romani10Stefano Brancorsini11Marina Maria Bellet12Department of Experimental Medicine, University of Perugia, Perugia, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia, ItalyReference Centre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia, ItalyDepartment of Veterinary Medicine, University of Perugia, Perugia, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia, ItalyThe organisms of most domains of life have adapted to circadian changes of the environment and regulate their behavior and physiology accordingly. A particular case of such paradigm is represented by some types of host-pathogen interaction during infection. Indeed, not only some hosts and pathogens are each endowed with their own circadian clock, but they are also influenced by the circadian changes of the other with profound consequences on the outcome of the infection. It comes that daily fluctuations in the availability of resources and the nature of the immune response, coupled with circadian changes of the pathogen, may influence microbial virulence, level of colonization and damage to the host, and alter the equilibrium between commensal and invading microorganisms. In the present review, we discuss the potential relevance of circadian rhythms in human bacterial and fungal pathogens, and the consequences of circadian changes of the host immune system and microbiome on the onset and development of infection. By looking from the perspective of the interplay between host and microbes circadian rhythms, these concepts are expected to change the way we approach human infections, not only by predicting the outcome of the host-pathogen interaction, but also by indicating the best time for intervention to potentiate the anti-microbial activities of the immune system and to weaken the pathogen when its susceptibility is higher.https://www.frontiersin.org/article/10.3389/fcimb.2020.00030/fullcircadian rhythmbacteriafungihostinfectionsimmune system |
| spellingShingle | Claudio Costantini Giorgia Renga Federica Sellitto Monica Borghi Claudia Stincardini Marilena Pariano Teresa Zelante Flavia Chiarotti Andrea Bartoli Paolo Mosci Luigina Romani Stefano Brancorsini Marina Maria Bellet Microbes in the Era of Circadian Medicine Frontiers in Cellular and Infection Microbiology circadian rhythm bacteria fungi host infections immune system |
| title | Microbes in the Era of Circadian Medicine |
| title_full | Microbes in the Era of Circadian Medicine |
| title_fullStr | Microbes in the Era of Circadian Medicine |
| title_full_unstemmed | Microbes in the Era of Circadian Medicine |
| title_short | Microbes in the Era of Circadian Medicine |
| title_sort | microbes in the era of circadian medicine |
| topic | circadian rhythm bacteria fungi host infections immune system |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2020.00030/full |
| work_keys_str_mv | AT claudiocostantini microbesintheeraofcircadianmedicine AT giorgiarenga microbesintheeraofcircadianmedicine AT federicasellitto microbesintheeraofcircadianmedicine AT monicaborghi microbesintheeraofcircadianmedicine AT claudiastincardini microbesintheeraofcircadianmedicine AT marilenapariano microbesintheeraofcircadianmedicine AT teresazelante microbesintheeraofcircadianmedicine AT flaviachiarotti microbesintheeraofcircadianmedicine AT andreabartoli microbesintheeraofcircadianmedicine AT paolomosci microbesintheeraofcircadianmedicine AT luiginaromani microbesintheeraofcircadianmedicine AT stefanobrancorsini microbesintheeraofcircadianmedicine AT marinamariabellet microbesintheeraofcircadianmedicine |