Reactogenicity and Humoral Immune Response after Heterologous Vaxzevria/Comirnaty Vaccination in a Group of Individuals Vaccinated in the AOU Policlinic “G. Martino” (Messina, Italy): A Retrospective Cohort Study
On 11 June 2021, the Italian Ministry of Health authorized the heterologous vaccination schedule. The goals of our retrospective study were to (a) evaluate the undesirable effects after the administration of Vaxzevria and Comirnaty vaccines; (b) evaluate the antibody response after 28 days from the...
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MDPI AG
2022-10-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/11/1803 |
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| author | Roberto Venuto Ioselita Giunta Mario Vaccaro Vincenza La Fauci Concetta Ceccio Francesco Fedele Antonino Privitera Federica Denaro Giuseppe Pantò Rosaria Cortese Giovanna Visalli Smeralda D’Amato Andrea Squeri Raffaele Squeri Cristina Genovese |
| author_facet | Roberto Venuto Ioselita Giunta Mario Vaccaro Vincenza La Fauci Concetta Ceccio Francesco Fedele Antonino Privitera Federica Denaro Giuseppe Pantò Rosaria Cortese Giovanna Visalli Smeralda D’Amato Andrea Squeri Raffaele Squeri Cristina Genovese |
| author_sort | Roberto Venuto |
| collection | DOAJ |
| description | On 11 June 2021, the Italian Ministry of Health authorized the heterologous vaccination schedule. The goals of our retrospective study were to (a) evaluate the undesirable effects after the administration of Vaxzevria and Comirnaty vaccines; (b) evaluate the antibody response after 28 days from the administration of the second dose; and (c) compare the antibody responses after the homologous and heterologous vaccination regimens. The undesirable effects were collected using a survey; IgG Spike was quantified using the electrochemiluminescence method; the comparison between the antibody responses was carried out using the sample of a homologous vaccine schedule previously analyzed. Pain at the injection site is the most common undesirable effect after the administration of both vaccines (62.1% after Vaxzevria vs. 82.75% after Comirnaty); swelling at the injection site is more frequent after the administration of Vaxzevria than after the administration of Comirnaty: (15.52% vs. 5.17%); headache is more frequent in women than in men for both the vaccination types (<i>p</i> < 0.05); 49.09% of the sample reported IgG Spike ≥ 12,500 U/mL; the antibody titer of the heterologous schedule is higher than that of the homologous vaccination. Our study demonstrated that the undesirable effects after the administration of the second dose are less frequent and less severe than after the administration of the first dose, and that the immunogenicity of the heterologous vaccinations is higher than that of the homologous ones. |
| first_indexed | 2024-03-09T18:35:14Z |
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| id | doaj.art-66d7d0d004974dfda1df4eda334fcb4f |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T18:35:14Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-66d7d0d004974dfda1df4eda334fcb4f2023-11-24T07:12:59ZengMDPI AGVaccines2076-393X2022-10-011011180310.3390/vaccines10111803Reactogenicity and Humoral Immune Response after Heterologous Vaxzevria/Comirnaty Vaccination in a Group of Individuals Vaccinated in the AOU Policlinic “G. Martino” (Messina, Italy): A Retrospective Cohort StudyRoberto Venuto0Ioselita Giunta1Mario Vaccaro2Vincenza La Fauci3Concetta Ceccio4Francesco Fedele5Antonino Privitera6Federica Denaro7Giuseppe Pantò8Rosaria Cortese9Giovanna Visalli10Smeralda D’Amato11Andrea Squeri12Raffaele Squeri13Cristina Genovese14Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Clinical and Experimental Medicine, Unit of Dermatology, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Human Patology “G. Barresi”, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, ItalyOn 11 June 2021, the Italian Ministry of Health authorized the heterologous vaccination schedule. The goals of our retrospective study were to (a) evaluate the undesirable effects after the administration of Vaxzevria and Comirnaty vaccines; (b) evaluate the antibody response after 28 days from the administration of the second dose; and (c) compare the antibody responses after the homologous and heterologous vaccination regimens. The undesirable effects were collected using a survey; IgG Spike was quantified using the electrochemiluminescence method; the comparison between the antibody responses was carried out using the sample of a homologous vaccine schedule previously analyzed. Pain at the injection site is the most common undesirable effect after the administration of both vaccines (62.1% after Vaxzevria vs. 82.75% after Comirnaty); swelling at the injection site is more frequent after the administration of Vaxzevria than after the administration of Comirnaty: (15.52% vs. 5.17%); headache is more frequent in women than in men for both the vaccination types (<i>p</i> < 0.05); 49.09% of the sample reported IgG Spike ≥ 12,500 U/mL; the antibody titer of the heterologous schedule is higher than that of the homologous vaccination. Our study demonstrated that the undesirable effects after the administration of the second dose are less frequent and less severe than after the administration of the first dose, and that the immunogenicity of the heterologous vaccinations is higher than that of the homologous ones.https://www.mdpi.com/2076-393X/10/11/1803COVID-19ComirnatyVaxzevriaheterologous vaccination regimen COVID-19homologous vaccination regimen COVID-19 |
| spellingShingle | Roberto Venuto Ioselita Giunta Mario Vaccaro Vincenza La Fauci Concetta Ceccio Francesco Fedele Antonino Privitera Federica Denaro Giuseppe Pantò Rosaria Cortese Giovanna Visalli Smeralda D’Amato Andrea Squeri Raffaele Squeri Cristina Genovese Reactogenicity and Humoral Immune Response after Heterologous Vaxzevria/Comirnaty Vaccination in a Group of Individuals Vaccinated in the AOU Policlinic “G. Martino” (Messina, Italy): A Retrospective Cohort Study Vaccines COVID-19 Comirnaty Vaxzevria heterologous vaccination regimen COVID-19 homologous vaccination regimen COVID-19 |
| title | Reactogenicity and Humoral Immune Response after Heterologous Vaxzevria/Comirnaty Vaccination in a Group of Individuals Vaccinated in the AOU Policlinic “G. Martino” (Messina, Italy): A Retrospective Cohort Study |
| title_full | Reactogenicity and Humoral Immune Response after Heterologous Vaxzevria/Comirnaty Vaccination in a Group of Individuals Vaccinated in the AOU Policlinic “G. Martino” (Messina, Italy): A Retrospective Cohort Study |
| title_fullStr | Reactogenicity and Humoral Immune Response after Heterologous Vaxzevria/Comirnaty Vaccination in a Group of Individuals Vaccinated in the AOU Policlinic “G. Martino” (Messina, Italy): A Retrospective Cohort Study |
| title_full_unstemmed | Reactogenicity and Humoral Immune Response after Heterologous Vaxzevria/Comirnaty Vaccination in a Group of Individuals Vaccinated in the AOU Policlinic “G. Martino” (Messina, Italy): A Retrospective Cohort Study |
| title_short | Reactogenicity and Humoral Immune Response after Heterologous Vaxzevria/Comirnaty Vaccination in a Group of Individuals Vaccinated in the AOU Policlinic “G. Martino” (Messina, Italy): A Retrospective Cohort Study |
| title_sort | reactogenicity and humoral immune response after heterologous vaxzevria comirnaty vaccination in a group of individuals vaccinated in the aou policlinic g martino messina italy a retrospective cohort study |
| topic | COVID-19 Comirnaty Vaxzevria heterologous vaccination regimen COVID-19 homologous vaccination regimen COVID-19 |
| url | https://www.mdpi.com/2076-393X/10/11/1803 |
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