Acute effects of exercise with blood flow restriction on endothelial function in healthy young and older populations: a systematic review
The objective of this review is to identify the acute effects of blood flow restriction (BFR) with vs without exercise on endothelial function in healthy individuals and the changes in endothelial function in young and older adults following different levels of exclusive BFR vs free flow. Systematic...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Geriatrics and Gerontology
2023-04-01
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| Series: | Geriatrics, Gerontology and Aging |
| Subjects: | |
| Online Access: | https://ggaging.com/details/1770/en-US/acute-effects-of-exercise-with-blood-flow-restriction-on-endothelial-function-in-healthy-young-and-older-populations--a-systematic-review |
| _version_ | 1797838906920534016 |
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| author | Gustavo Gonçalves Cardozo Karynne Grutter Lopes Daniel Alexandre Bottino Maria das Graças Coelho de Souza Eliete Bouskela Paulo Farinatti Ricardo Brandão de Oliveira |
| author_facet | Gustavo Gonçalves Cardozo Karynne Grutter Lopes Daniel Alexandre Bottino Maria das Graças Coelho de Souza Eliete Bouskela Paulo Farinatti Ricardo Brandão de Oliveira |
| author_sort | Gustavo Gonçalves Cardozo |
| collection | DOAJ |
| description | The objective of this review is to identify the acute effects of blood flow restriction (BFR) with vs without exercise on endothelial function in healthy individuals and the changes in endothelial function in young and older adults following different levels of exclusive BFR vs free flow. Systematic searches were performed in the following databases: PubMed, Web of Science, Scopus, and Cochrane Library, from inception to July 17, 2021. The studies included healthy individuals who underwent assessments of endothelial function before and after experimental protocols through endothelium-dependent flow-mediated dilatation. In total, 4890 studies were screened, and 6 studies of moderate-to-high methodological quality (Physiotherapy Evidence Database scores 6 - 10) including 82 subjects (aged 24 - 68 years) were eligible. Overall, flow-mediated dilatation increased in the non-cuffed arm immediately and 15 minutes after exercise, with no change in the cuffed arm (BFR of 60 - 80 mmHg). In protocols without exercise, cuff pressures of 25 - 30 mmHg applied for 30 minutes did not promote changes in the endothelial function, while those > 50 mmHg induced a dose-dependent attenuation of flow-mediated dilatation only in young individuals. A moderate level of BFR appears to have no effect on endothelial function after acute exercise. In non-exercise conditions, reductions in flow-mediated dilatation seem to result from increased retrograde shear provoked by cuff pressures ≥ 50 mmHg in young but not in older adults. An exercise-related increase in antegrade shear rate leads to a greater nitric oxide-mediated vasodilator response. However, BFR appears to attenuate this effect in young but not in older individuals. |
| first_indexed | 2024-04-09T15:49:38Z |
| format | Article |
| id | doaj.art-66d8e0edf9f94697a7c2683e819f21fc |
| institution | Directory Open Access Journal |
| issn | 2447-2123 |
| language | English |
| last_indexed | 2024-04-09T15:49:38Z |
| publishDate | 2023-04-01 |
| publisher | Brazilian Society of Geriatrics and Gerontology |
| record_format | Article |
| series | Geriatrics, Gerontology and Aging |
| spelling | doaj.art-66d8e0edf9f94697a7c2683e819f21fc2023-04-26T11:51:48ZengBrazilian Society of Geriatrics and GerontologyGeriatrics, Gerontology and Aging2447-21232023-04-01171810.53886/gga.e0230006Acute effects of exercise with blood flow restriction on endothelial function in healthy young and older populations: a systematic reviewGustavo Gonçalves Cardozo0https://orcid.org/0000-0003-3806-7895Karynne Grutter Lopes1https://orcid.org/0000-0003-3806-7895Daniel Alexandre Bottino2https://orcid.org/0000-0003-3806-7895Maria das Graças Coelho de Souza3https://orcid.org/0000-0003-3806-7895Eliete Bouskela4https://orcid.org/0000-0003-3806-7895Paulo Farinatti5https://orcid.org/0000-0003-3806-7895Ricardo Brandão de Oliveira6https://orcid.org/0000-0003-3806-7895Programa de pós-graduação em Ciências do Exercício e do Esporte, Universidade do Estado do Rio de Janeiro - Rio de Janeiro (RJ), Brazil.Programa de pós-graduação em Fisiopatologia Clínica e Experimental, Universidade do Estado do Rio de Janeiro - Rio de Janeiro (RJ), Brazil.Programa de pós-graduação em Fisiopatologia Clínica e Experimental, Universidade do Estado do Rio de Janeiro - Rio de Janeiro (RJ), Brazil.Programa de pós-graduação em Fisiopatologia Clínica e Experimental, Universidade do Estado do Rio de Janeiro - Rio de Janeiro (RJ), Brazil.Programa de pós-graduação em Fisiopatologia Clínica e Experimental, Universidade do Estado do Rio de Janeiro - Rio de Janeiro (RJ), Brazil.Programa de pós-graduação em Ciências do Exercício e do Esporte, Universidade do Estado do Rio de Janeiro - Rio de Janeiro (RJ), Brazil.Programa de pós-graduação em Ciências do Exercício e do Esporte, Universidade do Estado do Rio de Janeiro - Rio de Janeiro (RJ), Brazil.The objective of this review is to identify the acute effects of blood flow restriction (BFR) with vs without exercise on endothelial function in healthy individuals and the changes in endothelial function in young and older adults following different levels of exclusive BFR vs free flow. Systematic searches were performed in the following databases: PubMed, Web of Science, Scopus, and Cochrane Library, from inception to July 17, 2021. The studies included healthy individuals who underwent assessments of endothelial function before and after experimental protocols through endothelium-dependent flow-mediated dilatation. In total, 4890 studies were screened, and 6 studies of moderate-to-high methodological quality (Physiotherapy Evidence Database scores 6 - 10) including 82 subjects (aged 24 - 68 years) were eligible. Overall, flow-mediated dilatation increased in the non-cuffed arm immediately and 15 minutes after exercise, with no change in the cuffed arm (BFR of 60 - 80 mmHg). In protocols without exercise, cuff pressures of 25 - 30 mmHg applied for 30 minutes did not promote changes in the endothelial function, while those > 50 mmHg induced a dose-dependent attenuation of flow-mediated dilatation only in young individuals. A moderate level of BFR appears to have no effect on endothelial function after acute exercise. In non-exercise conditions, reductions in flow-mediated dilatation seem to result from increased retrograde shear provoked by cuff pressures ≥ 50 mmHg in young but not in older adults. An exercise-related increase in antegrade shear rate leads to a greater nitric oxide-mediated vasodilator response. However, BFR appears to attenuate this effect in young but not in older individuals.https://ggaging.com/details/1770/en-US/acute-effects-of-exercise-with-blood-flow-restriction-on-endothelial-function-in-healthy-young-and-older-populations--a-systematic-reviewvasodilationmicrovascular blood flowexercisehealth |
| spellingShingle | Gustavo Gonçalves Cardozo Karynne Grutter Lopes Daniel Alexandre Bottino Maria das Graças Coelho de Souza Eliete Bouskela Paulo Farinatti Ricardo Brandão de Oliveira Acute effects of exercise with blood flow restriction on endothelial function in healthy young and older populations: a systematic review Geriatrics, Gerontology and Aging vasodilation microvascular blood flow exercise health |
| title | Acute effects of exercise with blood flow restriction on endothelial function in healthy young and older populations: a systematic review |
| title_full | Acute effects of exercise with blood flow restriction on endothelial function in healthy young and older populations: a systematic review |
| title_fullStr | Acute effects of exercise with blood flow restriction on endothelial function in healthy young and older populations: a systematic review |
| title_full_unstemmed | Acute effects of exercise with blood flow restriction on endothelial function in healthy young and older populations: a systematic review |
| title_short | Acute effects of exercise with blood flow restriction on endothelial function in healthy young and older populations: a systematic review |
| title_sort | acute effects of exercise with blood flow restriction on endothelial function in healthy young and older populations a systematic review |
| topic | vasodilation microvascular blood flow exercise health |
| url | https://ggaging.com/details/1770/en-US/acute-effects-of-exercise-with-blood-flow-restriction-on-endothelial-function-in-healthy-young-and-older-populations--a-systematic-review |
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