The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors
Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria. The diversity of the insecticide arsenal has remained stagnant for decades, but the recent rise of insecticide...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000100001&lng=en&tlng=en |
| _version_ | 1797757258213359616 |
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| author | Michelle Ngai Mary Ann McDowell |
| author_facet | Michelle Ngai Mary Ann McDowell |
| author_sort | Michelle Ngai |
| collection | DOAJ |
| description | Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria. The diversity of the insecticide arsenal has remained stagnant for decades, but the recent rise of insecticide resistance fueled the discovery of novel modes of action, and the power of genomics has reinvigorated this search. This review discusses the importance of comparative and functional insect genomics in the identification of potential gene targets for an insecticidal mode of action with low off-target toxicity. Due to the global participation in the sequencing and annotation of insect genomes, the targeting of specific genes with molecular tools like RNAi and CRISPR/Cas9 for genome engineering and consequent functional identification and validation has become more efficient. While there are multiple avenues to explore for insecticidal candidates, this review identifies G-protein coupled receptors as attractive targets, and hones in on the octopamine and dopamine receptors due to their potential. |
| first_indexed | 2024-03-12T18:13:16Z |
| format | Article |
| id | doaj.art-66da339ea8c442ec9f2f858ac17463f5 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:13:16Z |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-66da339ea8c442ec9f2f858ac17463f52023-08-02T09:13:55ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-806011211710.1590/0074-02760160345S0074-02762017000100001The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptorsMichelle NgaiMary Ann McDowellInsects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria. The diversity of the insecticide arsenal has remained stagnant for decades, but the recent rise of insecticide resistance fueled the discovery of novel modes of action, and the power of genomics has reinvigorated this search. This review discusses the importance of comparative and functional insect genomics in the identification of potential gene targets for an insecticidal mode of action with low off-target toxicity. Due to the global participation in the sequencing and annotation of insect genomes, the targeting of specific genes with molecular tools like RNAi and CRISPR/Cas9 for genome engineering and consequent functional identification and validation has become more efficient. While there are multiple avenues to explore for insecticidal candidates, this review identifies G-protein coupled receptors as attractive targets, and hones in on the octopamine and dopamine receptors due to their potential.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000100001&lng=en&tlng=engenomicsinsecticidesG-protein-coupled receptors |
| spellingShingle | Michelle Ngai Mary Ann McDowell The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors Memorias do Instituto Oswaldo Cruz genomics insecticides G-protein-coupled receptors |
| title | The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors |
| title_full | The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors |
| title_fullStr | The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors |
| title_full_unstemmed | The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors |
| title_short | The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors |
| title_sort | search for novel insecticide targets in the post genomics era with a specific focus on g protein coupled receptors |
| topic | genomics insecticides G-protein-coupled receptors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000100001&lng=en&tlng=en |
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