Restoration of Olfactory Memory in Drosophila Overexpressing Human Alzheimer’s Disease Associated Tau by Manipulation of L-Type Ca2+ Channels

Restoration of Olfactory Memory in Drosophila Overexpressing Human Alzheimer’s Disease Associated Tau by Manipulation of L-Type Ca2+ Channels

The cellular underpinnings of memory deficits in Alzheimer’s disease (AD) are poorly understood. We utilized the tractable neural circuits sub-serving memory in Drosophila to investigate the role of impaired Ca2+ handling in memory deficits caused by expression of human 0N4R isoform of tau which is...

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Bibliographic Details
Main Authors: James P. Higham, Sergio Hidalgo, Edgar Buhl, James J. L. Hodge
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
tau
tauopathy
Alzheimer’s disease
memory
L-type Ca2+ channels
Drosophila
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00409/full

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