Vitamin D status in a Brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infection
The purpose was to determine the prevalence and related factors of vitamin D (VitD) insufficiency in adolescents and young adults with perinatally acquired human immunodeficiency virus. A cohort of 65 patients (17.6 ± 2 years) at the Federal University of Rio de Janeiro, Brazil, were examined for pu...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2016-02-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000200128&lng=en&tlng=en |
| _version_ | 1797758439779205120 |
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| author | Annie Schtscherbyna Carla Gouveia Maria Fernanda Miguens Castelar Pinheiro Ronir Raggio Luiz Maria Lucia Fleiuss Farias Elizabeth Stankiewicz Machado |
| author_facet | Annie Schtscherbyna Carla Gouveia Maria Fernanda Miguens Castelar Pinheiro Ronir Raggio Luiz Maria Lucia Fleiuss Farias Elizabeth Stankiewicz Machado |
| author_sort | Annie Schtscherbyna |
| collection | DOAJ |
| description | The purpose was to determine the prevalence and related factors of vitamin D (VitD) insufficiency in adolescents and young adults with perinatally acquired human immunodeficiency virus. A cohort of 65 patients (17.6 ± 2 years) at the Federal University of Rio de Janeiro, Brazil, were examined for pubertal development, nutrition, serum parathormone and serum 25-hydroxyvitamin D [s25(OH)D]. s25(OH)D levels < 30 ng/mL (< 75 nmol/L) were defined as VitD insufficiency. CD4+ T-cell counts and viral load, history of worst clinical status, immunologic status as nadir, current immunologic status, and antiretroviral (ART) regimen were also evaluated as risk factors for VitD insufficiency. Mean s25(OH)D was 37.7 ± 13.9 ng/mL and 29.2% had VitD insufficiency. There was no difference between VitD status and gender, age, nutritional status, clinical and immunological classification, and type of ART. Only VitD consumption showed tendency of association with s25(OH)D (p = 0.064). Individuals analysed in summer/autumn season had a higher s25(OH)D compared to the ones analysed in winter/spring (42.6 ± 14.9 vs. 34.0 ± 11.9, p = 0.011). Although, the frequency of VitD insufficiency did not differ statistically between the groups (summer/autumn 17.9% vs. winter/spring 37.8%, p = 0.102), we suggest to monitor s25(OH)D in seropositive adolescents and young adults, especially during winter/spring months, even in sunny regions. |
| first_indexed | 2024-03-12T18:30:00Z |
| format | Article |
| id | doaj.art-66dca48bf5c44f948b60b72a5070f350 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:30:00Z |
| publishDate | 2016-02-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-66dca48bf5c44f948b60b72a5070f3502023-08-02T08:19:31ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602016-02-01111212813310.1590/0074-02760150403S0074-02762016000200128Vitamin D status in a Brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infectionAnnie SchtscherbynaCarla GouveiaMaria Fernanda Miguens Castelar PinheiroRonir Raggio LuizMaria Lucia Fleiuss FariasElizabeth Stankiewicz MachadoThe purpose was to determine the prevalence and related factors of vitamin D (VitD) insufficiency in adolescents and young adults with perinatally acquired human immunodeficiency virus. A cohort of 65 patients (17.6 ± 2 years) at the Federal University of Rio de Janeiro, Brazil, were examined for pubertal development, nutrition, serum parathormone and serum 25-hydroxyvitamin D [s25(OH)D]. s25(OH)D levels < 30 ng/mL (< 75 nmol/L) were defined as VitD insufficiency. CD4+ T-cell counts and viral load, history of worst clinical status, immunologic status as nadir, current immunologic status, and antiretroviral (ART) regimen were also evaluated as risk factors for VitD insufficiency. Mean s25(OH)D was 37.7 ± 13.9 ng/mL and 29.2% had VitD insufficiency. There was no difference between VitD status and gender, age, nutritional status, clinical and immunological classification, and type of ART. Only VitD consumption showed tendency of association with s25(OH)D (p = 0.064). Individuals analysed in summer/autumn season had a higher s25(OH)D compared to the ones analysed in winter/spring (42.6 ± 14.9 vs. 34.0 ± 11.9, p = 0.011). Although, the frequency of VitD insufficiency did not differ statistically between the groups (summer/autumn 17.9% vs. winter/spring 37.8%, p = 0.102), we suggest to monitor s25(OH)D in seropositive adolescents and young adults, especially during winter/spring months, even in sunny regions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000200128&lng=en&tlng=enadolescentperinatally acquired HIVvitamin DnutritionLatin America |
| spellingShingle | Annie Schtscherbyna Carla Gouveia Maria Fernanda Miguens Castelar Pinheiro Ronir Raggio Luiz Maria Lucia Fleiuss Farias Elizabeth Stankiewicz Machado Vitamin D status in a Brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infection Memorias do Instituto Oswaldo Cruz adolescent perinatally acquired HIV vitamin D nutrition Latin America |
| title | Vitamin D status in a Brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infection |
| title_full | Vitamin D status in a Brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infection |
| title_fullStr | Vitamin D status in a Brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infection |
| title_full_unstemmed | Vitamin D status in a Brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infection |
| title_short | Vitamin D status in a Brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infection |
| title_sort | vitamin d status in a brazilian cohort of adolescents and young adults with perinatally acquired human immunodeficiency virus infection |
| topic | adolescent perinatally acquired HIV vitamin D nutrition Latin America |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000200128&lng=en&tlng=en |
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