Five-mer peptides prevent short-term spatial memory deficits in Aβ25-35-induced Alzheimer’s model mouse by suppressing Aβ25-35 aggregation and resolving its aggregate form

Five-mer peptides prevent short-term spatial memory deficits in Aβ25-35-induced Alzheimer’s model mouse by suppressing Aβ25-35 aggregation and resolving its aggregate form

Abstract Background The development of drugs for Alzheimer’s disease (AD), which is related to the misfolding and aggregation of amyloid-β (Aβ), is high in demand due to the growing number of AD patients. In this study, we screened 22 kinds of 5-mer synthetic peptides derived from the Box A region o...

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Bibliographic Details
Main Authors: Rina Nakamura, Motomi Konishi, Youichirou Higashi, Motoaki Saito, Toshifumi Akizawa
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Amyloid β peptide
5-Mer synthetic peptide
Aggregation
ThT assay
Online Access:https://doi.org/10.1186/s13195-023-01229-2

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