Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist

Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist

The prevailing model for the variety in drug responses is that different drugs stabilize distinct active states of their G protein-coupled receptor (GPCR) targets, allowing coupling to different effectors. However, whether the same ligand generates different GPCR active states based on the immediate...

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Bibliographic Details
Main Authors: Stephanie E Crilly, Wooree Ko, Zara Y Weinberg, Manojkumar A Puthenveedu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
GPCR
spatial encoding
signaling
organelle
Online Access:https://elifesciences.org/articles/67478

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