Activation of ventral tegmental area vesicular GABA transporter (Vgat) neurons alleviates social defeat stress-induced anxiety in APP/PS1 mice

Activation of ventral tegmental area vesicular GABA transporter (Vgat) neurons alleviates social defeat stress-induced anxiety in APP/PS1 mice

IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disease that results in cognitive impairment and is often accompanied by anxiety. In this study, we investigated whether the activation of VTAVgat neurons could reduce anxiety in APP/PS1 mice. We hypothesized that acute social d...

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Bibliographic Details
Main Authors: Di Yao, Rong Li, Musa Kora, Hongqing Huang, Xinghua Liu, Song Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
social defeat stress model
ventral tegmental area (VTA)
GABA neuron
sleep
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1142055/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1142055/full

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