SRAdb: query and use public next-generation sequencing data from within R
<p>Abstract</p> <p>Background</p> <p>The Sequence Read Archive (SRA) is the largest public repository of sequencing data from the next generation of sequencing platforms including Illumina (Genome Analyzer, HiSeq, MiSeq, .etc), Roche 454 GS System, Applied Biosystems SO...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2013-01-01
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| Series: | BMC Bioinformatics |
| Online Access: | http://www.biomedcentral.com/1471-2105/14/19 |
| _version_ | 1811294553151373312 |
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| author | Zhu Yuelin Stephens Robert M Meltzer Paul S Davis Sean R |
| author_facet | Zhu Yuelin Stephens Robert M Meltzer Paul S Davis Sean R |
| author_sort | Zhu Yuelin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The Sequence Read Archive (SRA) is the largest public repository of sequencing data from the next generation of sequencing platforms including Illumina (Genome Analyzer, HiSeq, MiSeq, .etc), Roche 454 GS System, Applied Biosystems SOLiD System, Helicos Heliscope, PacBio RS, and others.</p> <p>Results</p> <p>SRAdb is an attempt to make queries of the metadata associated with SRA submission, study, sample, experiment and run more robust and precise, and make access to sequencing data in the SRA easier. We have parsed all the SRA metadata into a SQLite database that is routinely updated and can be easily distributed. The SRAdb R/Bioconductor package then utilizes this SQLite database for querying and accessing metadata. Full text search functionality makes querying metadata very flexible and powerful. Fastq files associated with query results can be downloaded easily for local analysis. The package also includes an interface from R to a popular genome browser, the Integrated Genomics Viewer.</p> <p>Conclusions</p> <p>SRAdb Bioconductor package provides a convenient and integrated framework to query and access SRA metadata quickly and powerfully from within R.</p> |
| first_indexed | 2024-04-13T05:19:13Z |
| format | Article |
| id | doaj.art-66e34da473c84973ac0e320ba017882f |
| institution | Directory Open Access Journal |
| issn | 1471-2105 |
| language | English |
| last_indexed | 2024-04-13T05:19:13Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Bioinformatics |
| spelling | doaj.art-66e34da473c84973ac0e320ba017882f2022-12-22T03:00:48ZengBMCBMC Bioinformatics1471-21052013-01-011411910.1186/1471-2105-14-19SRAdb: query and use public next-generation sequencing data from within RZhu YuelinStephens Robert MMeltzer Paul SDavis Sean R<p>Abstract</p> <p>Background</p> <p>The Sequence Read Archive (SRA) is the largest public repository of sequencing data from the next generation of sequencing platforms including Illumina (Genome Analyzer, HiSeq, MiSeq, .etc), Roche 454 GS System, Applied Biosystems SOLiD System, Helicos Heliscope, PacBio RS, and others.</p> <p>Results</p> <p>SRAdb is an attempt to make queries of the metadata associated with SRA submission, study, sample, experiment and run more robust and precise, and make access to sequencing data in the SRA easier. We have parsed all the SRA metadata into a SQLite database that is routinely updated and can be easily distributed. The SRAdb R/Bioconductor package then utilizes this SQLite database for querying and accessing metadata. Full text search functionality makes querying metadata very flexible and powerful. Fastq files associated with query results can be downloaded easily for local analysis. The package also includes an interface from R to a popular genome browser, the Integrated Genomics Viewer.</p> <p>Conclusions</p> <p>SRAdb Bioconductor package provides a convenient and integrated framework to query and access SRA metadata quickly and powerfully from within R.</p>http://www.biomedcentral.com/1471-2105/14/19 |
| spellingShingle | Zhu Yuelin Stephens Robert M Meltzer Paul S Davis Sean R SRAdb: query and use public next-generation sequencing data from within R BMC Bioinformatics |
| title | SRAdb: query and use public next-generation sequencing data from within R |
| title_full | SRAdb: query and use public next-generation sequencing data from within R |
| title_fullStr | SRAdb: query and use public next-generation sequencing data from within R |
| title_full_unstemmed | SRAdb: query and use public next-generation sequencing data from within R |
| title_short | SRAdb: query and use public next-generation sequencing data from within R |
| title_sort | sradb query and use public next generation sequencing data from within r |
| url | http://www.biomedcentral.com/1471-2105/14/19 |
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