Dereplication Strategies for Targeted Isolation of New Antitrypanosomal Actinosporins A and B from a Marine Sponge Associated-Actinokineospora sp. EG49

Dereplication Strategies for Targeted Isolation of New Antitrypanosomal Actinosporins A and B from a Marine Sponge Associated-Actinokineospora sp. EG49

High resolution Fourier transform mass spectrometry (HRFTMS) and nuclear magnetic resonance (NMR) spectroscopy were employed as complementary metabolomic tools to dereplicate the chemical profile of the new and antitrypanosomally active sponge-associated bacterium Actinokineospora sp. EG49 extract....

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Bibliographic Details
Main Authors: Usama Ramadan Abdelmohsen, Cheng Cheng, Christina Viegelmann, Tong Zhang, Tanja Grkovic, Safwat Ahmed, Ronald J. Quinn, Ute Hentschel, RuAngelie Edrada-Ebel
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Marine Drugs
Subjects:
actinosporins
Spheciospongia vagabunda
Actinokineospora
anti-trypanosomal
dereplication
secondary metabolomics
Online Access:http://www.mdpi.com/1660-3397/12/3/1220

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