Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer?
Elisabetta Caselli,1 Irene Soffritti,1 Maria D’Accolti,1 Isabella Piva,2 Pantaleo Greco,2 Gloria Bonaccorsi2 1Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 2Section of Obstetrics and Gynecology, Department of Morphology...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-09-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/atopobium-vaginae-and-porphyromonas-somerae-induce-proinflammatory-cyt-peer-reviewed-article-CMAR |
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| author | Caselli E Soffritti I D'Accolti M Piva I Greco P Bonaccorsi G |
| author_facet | Caselli E Soffritti I D'Accolti M Piva I Greco P Bonaccorsi G |
| author_sort | Caselli E |
| collection | DOAJ |
| description | Elisabetta Caselli,1 Irene Soffritti,1 Maria D’Accolti,1 Isabella Piva,2 Pantaleo Greco,2 Gloria Bonaccorsi2 1Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 2Section of Obstetrics and Gynecology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, ItalyCorrespondence: Elisabetta CaselliSection of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, ItalyTel +39 0532 455387Fax +39 0532 974470Email csb@unife.itThe female lower vaginal tract has long been known to have an active microbiota, with Lactobacilli genus representing the prevalent species, and alterations in the vaginal microbiota are known to play a role in different pathological conditions, including bacterial vaginosis, sexually transmitted diseases, HPV persistence, and cervical cancer.By contrast, the uterus was considered sterile until recently, when the advent of next-generation sequencing (NGS) technologies identified a unique uterine microbiota differing from that of the vagina.1The uterine bacterial load is estimated to be 100–10,000-times lower than that of the vaginal microbiome, and, contrary to the vaginal and cervix microbiota, uterine bacteria grow in mildly alkaline conditions, contrasting to the Lactobacillus-dominated low pH environment of the vagina.2 |
| first_indexed | 2024-12-12T19:13:23Z |
| format | Article |
| id | doaj.art-66e6199772d44439a9d0edbfb1b0f435 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-12T19:13:23Z |
| publishDate | 2019-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-66e6199772d44439a9d0edbfb1b0f4352022-12-22T00:14:47ZengDove Medical PressCancer Management and Research1179-13222019-09-01Volume 118571857548755Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer?Caselli ESoffritti ID'Accolti MPiva IGreco PBonaccorsi GElisabetta Caselli,1 Irene Soffritti,1 Maria D’Accolti,1 Isabella Piva,2 Pantaleo Greco,2 Gloria Bonaccorsi2 1Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 2Section of Obstetrics and Gynecology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, ItalyCorrespondence: Elisabetta CaselliSection of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, ItalyTel +39 0532 455387Fax +39 0532 974470Email csb@unife.itThe female lower vaginal tract has long been known to have an active microbiota, with Lactobacilli genus representing the prevalent species, and alterations in the vaginal microbiota are known to play a role in different pathological conditions, including bacterial vaginosis, sexually transmitted diseases, HPV persistence, and cervical cancer.By contrast, the uterus was considered sterile until recently, when the advent of next-generation sequencing (NGS) technologies identified a unique uterine microbiota differing from that of the vagina.1The uterine bacterial load is estimated to be 100–10,000-times lower than that of the vaginal microbiome, and, contrary to the vaginal and cervix microbiota, uterine bacteria grow in mildly alkaline conditions, contrasting to the Lactobacillus-dominated low pH environment of the vagina.2https://www.dovepress.com/atopobium-vaginae-and-porphyromonas-somerae-induce-proinflammatory-cyt-peer-reviewed-article-CMARendometriummicrobiotacancerinflammatory environment |
| spellingShingle | Caselli E Soffritti I D'Accolti M Piva I Greco P Bonaccorsi G Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer? Cancer Management and Research endometrium microbiota cancer inflammatory environment |
| title | Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer? |
| title_full | Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer? |
| title_fullStr | Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer? |
| title_full_unstemmed | Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer? |
| title_short | Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer? |
| title_sort | atopobium vaginae and porphyromonas somerae induce proinflammatory cytokines expression in endometrial cells a possible implication for endometrial cancer |
| topic | endometrium microbiota cancer inflammatory environment |
| url | https://www.dovepress.com/atopobium-vaginae-and-porphyromonas-somerae-induce-proinflammatory-cyt-peer-reviewed-article-CMAR |
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