NOP Receptor Agonist Ro 64-6198 Decreases Escalation of Cocaine Self-Administration in Rats Genetically Selected for Alcohol Preference

NOP Receptor Agonist Ro 64-6198 Decreases Escalation of Cocaine Self-Administration in Rats Genetically Selected for Alcohol Preference

Cocaine dependence is a psychiatric condition for which effective medications are still lacking. Published data indicate that an increase in nociceptin/orphanin FQ (N/OFQ) transmission by NOP receptor activation attenuates cocaine-induced place conditioning and the locomotor sensitization effects of...

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Bibliographic Details
Main Authors: Hongwu Li, Giulia Scuppa, Qianwei Shen, Alessio Masi, Cinzia Nasuti, Nazzareno Cannella, Roberto Ciccocioppo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Psychiatry
Subjects:
abuse
addiction
psychostimulants
drug-seeking
opioids
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00176/full

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