Controllable protein phase separation and modular recruitment to form responsive membraneless organelles
Designer organelles with new biochemical functionalities are of great interest in synthetic biology and cellular engineering. Here the authors present a single-protein-based platform for generating synthetic membraneless compartments that is capable of enzymatically-triggered alterations to phase be...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05403-1 |
| _version_ | 1818842023666384896 |
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| author | Benjamin S. Schuster Ellen H. Reed Ranganath Parthasarathy Craig N. Jahnke Reese M. Caldwell Jessica G. Bermudez Holly Ramage Matthew C. Good Daniel A. Hammer |
| author_facet | Benjamin S. Schuster Ellen H. Reed Ranganath Parthasarathy Craig N. Jahnke Reese M. Caldwell Jessica G. Bermudez Holly Ramage Matthew C. Good Daniel A. Hammer |
| author_sort | Benjamin S. Schuster |
| collection | DOAJ |
| description | Designer organelles with new biochemical functionalities are of great interest in synthetic biology and cellular engineering. Here the authors present a single-protein-based platform for generating synthetic membraneless compartments that is capable of enzymatically-triggered alterations to phase behavior and of recruiting and concentrating cargo proteins. |
| first_indexed | 2024-12-19T04:35:23Z |
| format | Article |
| id | doaj.art-66e8162a85c44e12a7eb131604d160da |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:35:23Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-66e8162a85c44e12a7eb131604d160da2022-12-21T20:35:46ZengNature PortfolioNature Communications2041-17232018-07-019111210.1038/s41467-018-05403-1Controllable protein phase separation and modular recruitment to form responsive membraneless organellesBenjamin S. Schuster0Ellen H. Reed1Ranganath Parthasarathy2Craig N. Jahnke3Reese M. Caldwell4Jessica G. Bermudez5Holly Ramage6Matthew C. Good7Daniel A. Hammer8Department of Bioengineering, University of PennsylvaniaDepartment of Chemical and Biomolecular Engineering, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaDepartment of Chemical and Biomolecular Engineering, University of PennsylvaniaDepartment of Cell and Developmental Biology, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaDepartment of Microbiology, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaDesigner organelles with new biochemical functionalities are of great interest in synthetic biology and cellular engineering. Here the authors present a single-protein-based platform for generating synthetic membraneless compartments that is capable of enzymatically-triggered alterations to phase behavior and of recruiting and concentrating cargo proteins.https://doi.org/10.1038/s41467-018-05403-1 |
| spellingShingle | Benjamin S. Schuster Ellen H. Reed Ranganath Parthasarathy Craig N. Jahnke Reese M. Caldwell Jessica G. Bermudez Holly Ramage Matthew C. Good Daniel A. Hammer Controllable protein phase separation and modular recruitment to form responsive membraneless organelles Nature Communications |
| title | Controllable protein phase separation and modular recruitment to form responsive membraneless organelles |
| title_full | Controllable protein phase separation and modular recruitment to form responsive membraneless organelles |
| title_fullStr | Controllable protein phase separation and modular recruitment to form responsive membraneless organelles |
| title_full_unstemmed | Controllable protein phase separation and modular recruitment to form responsive membraneless organelles |
| title_short | Controllable protein phase separation and modular recruitment to form responsive membraneless organelles |
| title_sort | controllable protein phase separation and modular recruitment to form responsive membraneless organelles |
| url | https://doi.org/10.1038/s41467-018-05403-1 |
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