B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is still a major threat to mankind, urgently requiring improved vaccination and therapeutic strategies to reduce TB-disease burden. Most present vaccination strategies mainly aim to induce cell-mediated immunity (CMI), yet a series of in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.640168/full |
| _version_ | 1819291656635023360 |
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| author | Willemijn F. Rijnink Tom H.M. Ottenhoff Simone A. Joosten |
| author_facet | Willemijn F. Rijnink Tom H.M. Ottenhoff Simone A. Joosten |
| author_sort | Willemijn F. Rijnink |
| collection | DOAJ |
| description | Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is still a major threat to mankind, urgently requiring improved vaccination and therapeutic strategies to reduce TB-disease burden. Most present vaccination strategies mainly aim to induce cell-mediated immunity (CMI), yet a series of independent studies has shown that B-cells and antibodies (Abs) may contribute significantly to reduce the mycobacterial burden. Although early studies using B-cell knock out animals did not support a major role for B-cells, more recent studies have provided new evidence that B-cells and Abs can contribute significantly to host defense against Mtb. B-cells and Abs exist in many different functional subsets, each equipped with unique functional properties. In this review, we will summarize current evidence on the contribution of B-cells and Abs to immunity toward Mtb, their potential utility as biomarkers, and their functional contribution to Mtb control. |
| first_indexed | 2024-12-24T03:42:06Z |
| format | Article |
| id | doaj.art-66e9a5a87f1d43ac9f42414b2f93ecf3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-24T03:42:06Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-66e9a5a87f1d43ac9f42414b2f93ecf32022-12-21T17:16:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011210.3389/fimmu.2021.640168640168B-Cells and Antibodies as Contributors to Effector Immune Responses in TuberculosisWillemijn F. RijninkTom H.M. OttenhoffSimone A. JoostenTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is still a major threat to mankind, urgently requiring improved vaccination and therapeutic strategies to reduce TB-disease burden. Most present vaccination strategies mainly aim to induce cell-mediated immunity (CMI), yet a series of independent studies has shown that B-cells and antibodies (Abs) may contribute significantly to reduce the mycobacterial burden. Although early studies using B-cell knock out animals did not support a major role for B-cells, more recent studies have provided new evidence that B-cells and Abs can contribute significantly to host defense against Mtb. B-cells and Abs exist in many different functional subsets, each equipped with unique functional properties. In this review, we will summarize current evidence on the contribution of B-cells and Abs to immunity toward Mtb, their potential utility as biomarkers, and their functional contribution to Mtb control.https://www.frontiersin.org/articles/10.3389/fimmu.2021.640168/fullMycobacterium tuberculosistuberculosishumoral immunityB-cellsantibodiesbiomarker |
| spellingShingle | Willemijn F. Rijnink Tom H.M. Ottenhoff Simone A. Joosten B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis Frontiers in Immunology Mycobacterium tuberculosis tuberculosis humoral immunity B-cells antibodies biomarker |
| title | B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis |
| title_full | B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis |
| title_fullStr | B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis |
| title_full_unstemmed | B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis |
| title_short | B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis |
| title_sort | b cells and antibodies as contributors to effector immune responses in tuberculosis |
| topic | Mycobacterium tuberculosis tuberculosis humoral immunity B-cells antibodies biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.640168/full |
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