Analysis of Single Nucleotide-Mutated Single-Cancer Cells Using the Combined Technologies of Single-Cell Microarray Chips and Peptide Nucleic Acid-DNA Probes

Analysis of Single Nucleotide-Mutated Single-Cancer Cells Using the Combined Technologies of Single-Cell Microarray Chips and Peptide Nucleic Acid-DNA Probes

Research into cancer cells that harbor gene mutations relating to anticancer drug-resistance at the single-cell level has focused on the diagnosis of, or treatment for, cancer. Several methods have been reported for detecting gene-mutated cells within a large number of non-mutated cells; however, ta...

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Bibliographic Details
Main Authors: Hajime Shigeto, Eriko Yamada, Mizuki Kitamatsu, Takashi Ohtsuki, Akira Iizuka, Yasuto Akiyama, Shohei Yamamura
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Micromachines
Subjects:
single-cell analysis
peptide nucleic acid (PNA) probe
cell microarray
single nucleotide mutation
T790M mutation
lung cancer
Online Access:https://www.mdpi.com/2072-666X/11/7/628

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