Angiogenesis and inflammatory bowel disease
Inflammatory bowel disease (IBD) has gained immense attention recently due primarily to increasing prevalence. The exact disease mechanism is still unknown. There is considerable evidence of interrelation between the mechanisms of angiogenesis and the chronic inflammation of IBD. This evidence was o...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2007-01-01
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| Series: | The Saudi Journal of Gastroenterology |
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| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2007;volume=13;issue=1;spage=37;epage=38;aulast=Azzam |
| _version_ | 1819047300728619008 |
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| author | Azzam Nahla |
| author_facet | Azzam Nahla |
| author_sort | Azzam Nahla |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) has gained immense attention recently due primarily to increasing prevalence. The exact disease mechanism is still unknown. There is considerable evidence of interrelation between the mechanisms of angiogenesis and the chronic inflammation of IBD. This evidence was obtained from animal models of colitis and confirmed in human studies. Serum levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF) have been found to be significantly higher in patients with IBD than in controls. In addition, it was found that these factors correlate well with disease activity and decrease with the use of steroids. Therefore pharmacological inhibition of angiogenesis has the potential to be a therapeutic strategy in IBD. |
| first_indexed | 2024-12-21T10:58:11Z |
| format | Article |
| id | doaj.art-66ea76fc34f14538be5f88f4b6260b2f |
| institution | Directory Open Access Journal |
| issn | 1319-3767 |
| language | English |
| last_indexed | 2024-12-21T10:58:11Z |
| publishDate | 2007-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-66ea76fc34f14538be5f88f4b6260b2f2022-12-21T19:06:26ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37672007-01-011313738Angiogenesis and inflammatory bowel diseaseAzzam NahlaInflammatory bowel disease (IBD) has gained immense attention recently due primarily to increasing prevalence. The exact disease mechanism is still unknown. There is considerable evidence of interrelation between the mechanisms of angiogenesis and the chronic inflammation of IBD. This evidence was obtained from animal models of colitis and confirmed in human studies. Serum levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF) have been found to be significantly higher in patients with IBD than in controls. In addition, it was found that these factors correlate well with disease activity and decrease with the use of steroids. Therefore pharmacological inhibition of angiogenesis has the potential to be a therapeutic strategy in IBD.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2007;volume=13;issue=1;spage=37;epage=38;aulast=AzzamAngiogenesisinflammatory bowel disease |
| spellingShingle | Azzam Nahla Angiogenesis and inflammatory bowel disease The Saudi Journal of Gastroenterology Angiogenesis inflammatory bowel disease |
| title | Angiogenesis and inflammatory bowel disease |
| title_full | Angiogenesis and inflammatory bowel disease |
| title_fullStr | Angiogenesis and inflammatory bowel disease |
| title_full_unstemmed | Angiogenesis and inflammatory bowel disease |
| title_short | Angiogenesis and inflammatory bowel disease |
| title_sort | angiogenesis and inflammatory bowel disease |
| topic | Angiogenesis inflammatory bowel disease |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2007;volume=13;issue=1;spage=37;epage=38;aulast=Azzam |
| work_keys_str_mv | AT azzamnahla angiogenesisandinflammatoryboweldisease |