Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets
Venous thrombo-embolism (VTE) disease is the second most common cause of mortality in cancer patients, and evaluation and prevention of thrombosis risk is essential. VTE-associated risk varies according to the type of tumor disease. Oral cancer is the most frequent type of head and neck cancer, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/3/228 |
| _version_ | 1827588370818138112 |
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| author | Pierre Haen Lydie Crescence Diane Mege Alexandre Altié Christophe Dubois Laurence Panicot-Dubois |
| author_facet | Pierre Haen Lydie Crescence Diane Mege Alexandre Altié Christophe Dubois Laurence Panicot-Dubois |
| author_sort | Pierre Haen |
| collection | DOAJ |
| description | Venous thrombo-embolism (VTE) disease is the second most common cause of mortality in cancer patients, and evaluation and prevention of thrombosis risk is essential. VTE-associated risk varies according to the type of tumor disease. Oral cancer is the most frequent type of head and neck cancer, and it represents approximately 2.1% of all cancers worldwide. Most tumors are squamous cell carcinomas and are mainly due to tobacco and alcohol abuse. VTE risk associated with oral squamous cell carcinoma (OSCC) is low. However, many studies have shown that OSCC has the following biological features of cancers associated with a high thrombosis risk: modified thrombosis and fibrinolysis mechanisms; strong expression of procoagulant proteins; secretion of procoagulant microparticles; and production of procoagulant cytokines. Using an original mouse model of tongue squamous cell carcinoma, our study aimed to clarify this paradoxical situation. First, we showed that OSCC tumors have a pro-aggregatory phenotype and a high local thrombosis risk. Second, we found that tongue tumor mice do not have an elevated systemic thrombosis risk (the risk of an “at distance” thrombosis event such as lower extremity deep venous thrombosis or pulmonary embolism) and even show a reduction in risk. Third, we demonstrated that tongue tumor mice show a reduction in platelet reactivity, which explains the low systemic thrombosis risk. Finally, we found that tongue tumor mice present granule pool deficiency, thereby explaining the reduction in platelet reactivity and systemic thrombosis risk. |
| first_indexed | 2024-03-09T00:34:32Z |
| format | Article |
| id | doaj.art-66ebdfe1d484442cbd72b7193cc76642 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T00:34:32Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-66ebdfe1d484442cbd72b7193cc766422023-12-11T18:17:28ZengMDPI AGBiomedicines2227-90592021-02-019322810.3390/biomedicines9030228Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in PlateletsPierre Haen0Lydie Crescence1Diane Mege2Alexandre Altié3Christophe Dubois4Laurence Panicot-Dubois5Aix Marseille Université, INSERM 1263, INRAE, C2VN, 13885 Marseille, FranceAix Marseille Université, INSERM 1263, INRAE, C2VN, 13885 Marseille, FranceAix Marseille Université, INSERM 1263, INRAE, C2VN, 13885 Marseille, FranceAix Marseille Université, INSERM 1263, INRAE, C2VN, 13885 Marseille, FranceAix Marseille Université, INSERM 1263, INRAE, C2VN, 13885 Marseille, FranceAix Marseille Université, INSERM 1263, INRAE, C2VN, 13885 Marseille, FranceVenous thrombo-embolism (VTE) disease is the second most common cause of mortality in cancer patients, and evaluation and prevention of thrombosis risk is essential. VTE-associated risk varies according to the type of tumor disease. Oral cancer is the most frequent type of head and neck cancer, and it represents approximately 2.1% of all cancers worldwide. Most tumors are squamous cell carcinomas and are mainly due to tobacco and alcohol abuse. VTE risk associated with oral squamous cell carcinoma (OSCC) is low. However, many studies have shown that OSCC has the following biological features of cancers associated with a high thrombosis risk: modified thrombosis and fibrinolysis mechanisms; strong expression of procoagulant proteins; secretion of procoagulant microparticles; and production of procoagulant cytokines. Using an original mouse model of tongue squamous cell carcinoma, our study aimed to clarify this paradoxical situation. First, we showed that OSCC tumors have a pro-aggregatory phenotype and a high local thrombosis risk. Second, we found that tongue tumor mice do not have an elevated systemic thrombosis risk (the risk of an “at distance” thrombosis event such as lower extremity deep venous thrombosis or pulmonary embolism) and even show a reduction in risk. Third, we demonstrated that tongue tumor mice show a reduction in platelet reactivity, which explains the low systemic thrombosis risk. Finally, we found that tongue tumor mice present granule pool deficiency, thereby explaining the reduction in platelet reactivity and systemic thrombosis risk.https://www.mdpi.com/2227-9059/9/3/228disorders of platelet functionintravital microcopylaser injuryoral squamous cancerplatelet granules |
| spellingShingle | Pierre Haen Lydie Crescence Diane Mege Alexandre Altié Christophe Dubois Laurence Panicot-Dubois Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets Biomedicines disorders of platelet function intravital microcopy laser injury oral squamous cancer platelet granules |
| title | Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets |
| title_full | Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets |
| title_fullStr | Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets |
| title_full_unstemmed | Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets |
| title_short | Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets |
| title_sort | oral squamous cell carcinoma is associated with a low thrombosis risk due to storage pool deficiency in platelets |
| topic | disorders of platelet function intravital microcopy laser injury oral squamous cancer platelet granules |
| url | https://www.mdpi.com/2227-9059/9/3/228 |
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