Bioactive PI3-kinase/Akt/mTOR Inhibitors in Targeted Lung Cancer Therapy

One of the central signaling pathways with a regulatory effect on cell proliferation and survival is Akt/mTOR. In many human cancer types, for instance, lung cancer, the overexpression of Akt/mTOR has been reported. For this reason, either targeting cancer cells by synthetic or natural products affe...

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Main Authors: Somayyeh Ghareghomi, Vahideh Atabaki, Naseh Abdollahzadeh, Shahin Ahmadian, Salar Hafez Ghoran
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2023-01-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-13-24.pdf
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author Somayyeh Ghareghomi
Vahideh Atabaki
Naseh Abdollahzadeh
Shahin Ahmadian
Salar Hafez Ghoran
author_facet Somayyeh Ghareghomi
Vahideh Atabaki
Naseh Abdollahzadeh
Shahin Ahmadian
Salar Hafez Ghoran
author_sort Somayyeh Ghareghomi
collection DOAJ
description One of the central signaling pathways with a regulatory effect on cell proliferation and survival is Akt/mTOR. In many human cancer types, for instance, lung cancer, the overexpression of Akt/mTOR has been reported. For this reason, either targeting cancer cells by synthetic or natural products affecting the Akt/mTOR pathway down-regulation is a useful strategy in cancer therapy. Direct inhibition of the signaling pathway or modulation of each related molecule could have significant feedback on the growth and proliferation of cancer cells. A variety of secondary metabolites has been identified to directly inhibit the AKT/mTOR signaling, which is important in the field of drug discovery. Naturally occurring nitrogenous and phenolic compounds can emerge as two pivotal classes of natural products possessing anticancer abilities. Herein, we have summarized the alkaloids and flavonoids for lung cancer treatment together with all the possible mechanisms of action relying on the Akt/mTOR pathway down-regulation. This review suggested that in search of new drugs, phytochemicals could be considered as promising scaffolds to be developed into efficient drugs for the treatment of cancer. In this review, the terms "Akt/mTOR", "Alkaloid", "flavonoid", and "lung cancer" were searched without any limitation in search criteria in Scopus, PubMed, Web of Science, and Google scholar engines.
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spelling doaj.art-66ec6de640914c6494fe8433ef987a0b2023-09-26T10:13:00ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082023-01-01131243510.34172/apb.2023.003apb-32637Bioactive PI3-kinase/Akt/mTOR Inhibitors in Targeted Lung Cancer TherapySomayyeh Ghareghomi0Vahideh Atabaki1Naseh Abdollahzadeh2Shahin Ahmadian3Salar Hafez Ghoran4Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.Neurophysiology Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.One of the central signaling pathways with a regulatory effect on cell proliferation and survival is Akt/mTOR. In many human cancer types, for instance, lung cancer, the overexpression of Akt/mTOR has been reported. For this reason, either targeting cancer cells by synthetic or natural products affecting the Akt/mTOR pathway down-regulation is a useful strategy in cancer therapy. Direct inhibition of the signaling pathway or modulation of each related molecule could have significant feedback on the growth and proliferation of cancer cells. A variety of secondary metabolites has been identified to directly inhibit the AKT/mTOR signaling, which is important in the field of drug discovery. Naturally occurring nitrogenous and phenolic compounds can emerge as two pivotal classes of natural products possessing anticancer abilities. Herein, we have summarized the alkaloids and flavonoids for lung cancer treatment together with all the possible mechanisms of action relying on the Akt/mTOR pathway down-regulation. This review suggested that in search of new drugs, phytochemicals could be considered as promising scaffolds to be developed into efficient drugs for the treatment of cancer. In this review, the terms "Akt/mTOR", "Alkaloid", "flavonoid", and "lung cancer" were searched without any limitation in search criteria in Scopus, PubMed, Web of Science, and Google scholar engines.https://apb.tbzmed.ac.ir/PDF/apb-13-24.pdfalkaloidscancer treatmentdrug discoveryflavonoidslung cancerpi3k/akt/mtor
spellingShingle Somayyeh Ghareghomi
Vahideh Atabaki
Naseh Abdollahzadeh
Shahin Ahmadian
Salar Hafez Ghoran
Bioactive PI3-kinase/Akt/mTOR Inhibitors in Targeted Lung Cancer Therapy
Advanced Pharmaceutical Bulletin
alkaloids
cancer treatment
drug discovery
flavonoids
lung cancer
pi3k/akt/mtor
title Bioactive PI3-kinase/Akt/mTOR Inhibitors in Targeted Lung Cancer Therapy
title_full Bioactive PI3-kinase/Akt/mTOR Inhibitors in Targeted Lung Cancer Therapy
title_fullStr Bioactive PI3-kinase/Akt/mTOR Inhibitors in Targeted Lung Cancer Therapy
title_full_unstemmed Bioactive PI3-kinase/Akt/mTOR Inhibitors in Targeted Lung Cancer Therapy
title_short Bioactive PI3-kinase/Akt/mTOR Inhibitors in Targeted Lung Cancer Therapy
title_sort bioactive pi3 kinase akt mtor inhibitors in targeted lung cancer therapy
topic alkaloids
cancer treatment
drug discovery
flavonoids
lung cancer
pi3k/akt/mtor
url https://apb.tbzmed.ac.ir/PDF/apb-13-24.pdf
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AT vahidehatabaki bioactivepi3kinaseaktmtorinhibitorsintargetedlungcancertherapy
AT nasehabdollahzadeh bioactivepi3kinaseaktmtorinhibitorsintargetedlungcancertherapy
AT shahinahmadian bioactivepi3kinaseaktmtorinhibitorsintargetedlungcancertherapy
AT salarhafezghoran bioactivepi3kinaseaktmtorinhibitorsintargetedlungcancertherapy