Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse

Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse

TNF-α overexpression may contribute to motor neuron death in amyotrophic lateral sclerosis (ALS). We investigated the intracellular pathway associated with TNF-α in the wobbler mouse, a murine model of ALS, at the onset of symptoms. TNF-α and TNFR1 overexpression and JNK/p38MAPK phosphorylation occu...

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Bibliographic Details
Main Authors: Paolo Bigini, Mariaelena Repici, Giuseppina Cantarella, Elena Fumagalli, Sara Barbera, Alfredo Cagnotto, Ada De Luigi, Rossella Tonelli, Renato Bernardini, Tiziana Borsello, Tiziana Mennini
Format: Article
Language:English
Published: Elsevier 2008-03-01
Series:Neurobiology of Disease
Subjects:
TNFR1
rhTBP-1
p38MAPK
JNK
Motor neuron degeneration
Wobbler
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002513

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http://www.sciencedirect.com/science/article/pii/S0969996107002513

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