Study on the differences of reconstructive periodontium by stem cell sheets and normal periodontium under the orthodontic force
Objective To discuss the feasibility of orthodontic treatment for regenerated periodontal tissues by comparing the difference of tooth movement under orthodontic forces between the normal periodontal tissues and the reconstructed periodontal tissues by the composite cell sheets of dental follicle ce...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2016-07-01
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| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | http://manu45.magtech.com.cn/Jwk3_kqjbfz/EN/10.12016/j.issn.2096-1456.2016.07.004 |
| _version_ | 1818929165099859968 |
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| author | WU Qiong JIN Zuo-lin LI Xin WANG Li-ying LIU Jia |
| author_facet | WU Qiong JIN Zuo-lin LI Xin WANG Li-ying LIU Jia |
| author_sort | WU Qiong |
| collection | DOAJ |
| description | Objective To discuss the feasibility of orthodontic treatment for regenerated periodontal tissues by comparing the difference of tooth movement under orthodontic forces between the normal periodontal tissues and the reconstructed periodontal tissues by the composite cell sheets of dental follicle cells (DFCs) and periodontal ligament stem cells (PDLSCs).Methods Six adult male beagles were selected for experiment animals. The first premolar in all four quadrants of each beagle were extracted and a bone defect were made in the same size (4 mm × 4 mm × 4 mm) distal to the extraction sockets. The upper left and the lower right quadrants were divided into the regeneration group by transplantation of the composite cell sheets while the upper right and lower left quadrants were control group without transplantation. 12 weeks after transplantation, the orthodontic forces were introduced to move the second premolar mesially with a force value 150 g. Measurements were done after 4 weeks of traction to record the movement of the tooth. And compare the difference between the regeneration group and control group by the statistical analysis.Results DFCs/PDLSCs composite cell sheets repaired the periodontaltissue and formed the typical alveolar bone-periodontal membrane-cementum structurewhich shows good histological characteristics. experimental group and control group show no statistical difference in the rate of tooth movement (P > 0.05). Conclusion The periodontal tissues regenerated by this kind of the composite cell sheet showed a good response to mechanical stimulation. |
| first_indexed | 2024-12-20T03:40:28Z |
| format | Article |
| id | doaj.art-66ee5dc24968408abb43cc36e5162006 |
| institution | Directory Open Access Journal |
| issn | 2096-1456 2096-1456 |
| language | zho |
| last_indexed | 2024-12-20T03:40:28Z |
| publishDate | 2016-07-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-66ee5dc24968408abb43cc36e51620062022-12-21T19:54:45ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562096-14562016-07-0124739540110.12016/j.issn.2096-1456.2016.07.004Study on the differences of reconstructive periodontium by stem cell sheets and normal periodontium under the orthodontic forceWU Qiong0JIN Zuo-lin1LI Xin2WANG Li-ying3LIU Jia4State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Orthodontics, School of Stomatology, the Fourth Military Medical UniversityState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Orthodontics, School of Stomatology, the Fourth Military Medical UniversityState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Orthodontics, School of Stomatology, the Fourth Military Medical UniversityState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Orthodontics, School of Stomatology, the Fourth Military Medical UniversityState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Orthodontics, School of Stomatology, the Fourth Military Medical UniversityObjective To discuss the feasibility of orthodontic treatment for regenerated periodontal tissues by comparing the difference of tooth movement under orthodontic forces between the normal periodontal tissues and the reconstructed periodontal tissues by the composite cell sheets of dental follicle cells (DFCs) and periodontal ligament stem cells (PDLSCs).Methods Six adult male beagles were selected for experiment animals. The first premolar in all four quadrants of each beagle were extracted and a bone defect were made in the same size (4 mm × 4 mm × 4 mm) distal to the extraction sockets. The upper left and the lower right quadrants were divided into the regeneration group by transplantation of the composite cell sheets while the upper right and lower left quadrants were control group without transplantation. 12 weeks after transplantation, the orthodontic forces were introduced to move the second premolar mesially with a force value 150 g. Measurements were done after 4 weeks of traction to record the movement of the tooth. And compare the difference between the regeneration group and control group by the statistical analysis.Results DFCs/PDLSCs composite cell sheets repaired the periodontaltissue and formed the typical alveolar bone-periodontal membrane-cementum structurewhich shows good histological characteristics. experimental group and control group show no statistical difference in the rate of tooth movement (P > 0.05). Conclusion The periodontal tissues regenerated by this kind of the composite cell sheet showed a good response to mechanical stimulation.http://manu45.magtech.com.cn/Jwk3_kqjbfz/EN/10.12016/j.issn.2096-1456.2016.07.004Stem cellCell sheetPeriodontal regenerationDental follicle cellsOrthodontics |
| spellingShingle | WU Qiong JIN Zuo-lin LI Xin WANG Li-ying LIU Jia Study on the differences of reconstructive periodontium by stem cell sheets and normal periodontium under the orthodontic force 口腔疾病防治 Stem cell Cell sheet Periodontal regeneration Dental follicle cells Orthodontics |
| title | Study on the differences of reconstructive periodontium by stem cell sheets and normal periodontium under the orthodontic force |
| title_full | Study on the differences of reconstructive periodontium by stem cell sheets and normal periodontium under the orthodontic force |
| title_fullStr | Study on the differences of reconstructive periodontium by stem cell sheets and normal periodontium under the orthodontic force |
| title_full_unstemmed | Study on the differences of reconstructive periodontium by stem cell sheets and normal periodontium under the orthodontic force |
| title_short | Study on the differences of reconstructive periodontium by stem cell sheets and normal periodontium under the orthodontic force |
| title_sort | study on the differences of reconstructive periodontium by stem cell sheets and normal periodontium under the orthodontic force |
| topic | Stem cell Cell sheet Periodontal regeneration Dental follicle cells Orthodontics |
| url | http://manu45.magtech.com.cn/Jwk3_kqjbfz/EN/10.12016/j.issn.2096-1456.2016.07.004 |
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