Cerebrospinal Fluid Biomarkers in Parkinson’s Disease: A Critical Overview of the Literature and Meta-Analyses
Parkinson’s disease (PD) is a common neurodegenerative disorder; however, well-established biochemical markers have not yet been identified. This review article covers several candidate cerebrospinal fluid (CSF) biomarkers for PD based on the recent literature and meta-analysis data. The decrease of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/10/7/466 |
| _version_ | 1797561878525771776 |
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| author | Takayuki Katayama Jun Sawada Kae Takahashi Osamu Yahara |
| author_facet | Takayuki Katayama Jun Sawada Kae Takahashi Osamu Yahara |
| author_sort | Takayuki Katayama |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a common neurodegenerative disorder; however, well-established biochemical markers have not yet been identified. This review article covers several candidate cerebrospinal fluid (CSF) biomarkers for PD based on the recent literature and meta-analysis data. The decrease of α-synuclein in PD is supported by meta-analyses with modest reproducibility, and a decrease of amyloid β42 is seen as a prognostic marker for cognitive decline. Tau, phosphorylated tau (p-tau), and neurofilament light chains have been used to discriminate PD from other neurodegenerative disorders. This article also describes more hopeful biochemical markers, such as neurotransmitters, oxidative stress markers, and other candidate biomarkers. |
| first_indexed | 2024-03-10T18:20:49Z |
| format | Article |
| id | doaj.art-66eececba03c40db8a08843a82882e17 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T18:20:49Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-66eececba03c40db8a08843a82882e172023-11-20T07:20:57ZengMDPI AGBrain Sciences2076-34252020-07-0110746610.3390/brainsci10070466Cerebrospinal Fluid Biomarkers in Parkinson’s Disease: A Critical Overview of the Literature and Meta-AnalysesTakayuki Katayama0Jun Sawada1Kae Takahashi2Osamu Yahara3Department of Neurology, Asahikawa City Hospital, 1-1-65 Kinseicho, Asahikawa 070-8610, JapanDepartment of Neurology, Asahikawa Medical University Hospital, Asahikawa 078-8510, JapanDepartment of Neurology, Asahikawa City Hospital, 1-1-65 Kinseicho, Asahikawa 070-8610, JapanDepartment of Neurology, Asahikawa City Hospital, 1-1-65 Kinseicho, Asahikawa 070-8610, JapanParkinson’s disease (PD) is a common neurodegenerative disorder; however, well-established biochemical markers have not yet been identified. This review article covers several candidate cerebrospinal fluid (CSF) biomarkers for PD based on the recent literature and meta-analysis data. The decrease of α-synuclein in PD is supported by meta-analyses with modest reproducibility, and a decrease of amyloid β42 is seen as a prognostic marker for cognitive decline. Tau, phosphorylated tau (p-tau), and neurofilament light chains have been used to discriminate PD from other neurodegenerative disorders. This article also describes more hopeful biochemical markers, such as neurotransmitters, oxidative stress markers, and other candidate biomarkers.https://www.mdpi.com/2076-3425/10/7/466Parkinson’s diseasecerebrospinal fluidα-synucleinamyloid β42tauneurofilament light chain |
| spellingShingle | Takayuki Katayama Jun Sawada Kae Takahashi Osamu Yahara Cerebrospinal Fluid Biomarkers in Parkinson’s Disease: A Critical Overview of the Literature and Meta-Analyses Brain Sciences Parkinson’s disease cerebrospinal fluid α-synuclein amyloid β42 tau neurofilament light chain |
| title | Cerebrospinal Fluid Biomarkers in Parkinson’s Disease: A Critical Overview of the Literature and Meta-Analyses |
| title_full | Cerebrospinal Fluid Biomarkers in Parkinson’s Disease: A Critical Overview of the Literature and Meta-Analyses |
| title_fullStr | Cerebrospinal Fluid Biomarkers in Parkinson’s Disease: A Critical Overview of the Literature and Meta-Analyses |
| title_full_unstemmed | Cerebrospinal Fluid Biomarkers in Parkinson’s Disease: A Critical Overview of the Literature and Meta-Analyses |
| title_short | Cerebrospinal Fluid Biomarkers in Parkinson’s Disease: A Critical Overview of the Literature and Meta-Analyses |
| title_sort | cerebrospinal fluid biomarkers in parkinson s disease a critical overview of the literature and meta analyses |
| topic | Parkinson’s disease cerebrospinal fluid α-synuclein amyloid β42 tau neurofilament light chain |
| url | https://www.mdpi.com/2076-3425/10/7/466 |
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