| Summary: | We report herein the microwave assisted synthesis, without solvents and catalysts, of 6-substituted quinoxalines and 7-substituted pyrido[2,3<em>b</em>]pyrazines. The compounds were obtained in good yields and short reaction times using the mentioned procedure and two new structures are reported. A complete <sup>1</sup>H- and <sup>13</sup>C-NMR assignment was performed using 1D and 2D-NMR. Additionally, an <em>in vitro</em> screening was performed on Gram-positive and Gram-negative bacteria using amoxicillin as positive reference. Compounds bearing a pyridyl group tended to have higher antibacterial activity, but the best activity against <em>Bacillus subtilis</em> and <em>Proteus mirabilis</em> was observed with quinoxaline derivatives.
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