Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis
Objective: We aimed to determine the association between a polymorphism in the promoter region of the IL-1beta gene resulting in enhanced gene transcription and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Materials and Methods: The frequency of a single nuc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2021-12-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-70962&look4= |
| _version_ | 1797923080544190464 |
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| author | Alp Sarıteke İrem Fatma Uludağ Berk Özyılmaz Yaşar Zorlu Ufuk Şener Figen Tokuçoğlu |
| author_facet | Alp Sarıteke İrem Fatma Uludağ Berk Özyılmaz Yaşar Zorlu Ufuk Şener Figen Tokuçoğlu |
| author_sort | Alp Sarıteke |
| collection | DOAJ |
| description | Objective: We aimed to determine the association between a polymorphism in the promoter region of the IL-1beta gene resulting in enhanced gene transcription and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS).
Materials and Methods: The frequency of a single nucleotide polymorphism (SNP) that results in a C>T transition of 511 base pairs that are five prime to the transcription start site of the IL-1beta gene in a group of 21 patients with TLE+HS, 21 patients with temporal lobe epilepsy without hippocampal sclerosis (TLE-HS), and 23 healthy volunteers.
Results: The frequency of the -511T allele was 11/21 in the TLE-HS group, 13/21 in the TLE+HS group, and 12/23 in the control group. Chi-square analysis of genotype and allele distribution showed no significant difference between the patients in TLE+HS, TLE-HS, and control group
Conclusion: There was no association between the -511/C>T SNP variation and TLE+HS. |
| first_indexed | 2024-04-10T14:41:32Z |
| format | Article |
| id | doaj.art-66f0c4448d2d45d2a2fa7369d8cce573 |
| institution | Directory Open Access Journal |
| issn | 1309-2545 |
| language | English |
| last_indexed | 2024-04-10T14:41:32Z |
| publishDate | 2021-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-66f0c4448d2d45d2a2fa7369d8cce5732023-02-15T16:08:08ZengGalenos YayineviTürk Nöroloji Dergisi1309-25452021-12-0127439039310.4274/tnd.2021.70962Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal SclerosisAlp Sarıteke0https://orcid.org/0000-0003-3528-8297İrem Fatma Uludağ1https://orcid.org/0000-0003-2919-2141Berk Özyılmaz2https://orcid.org/0000-0003-2654-3698Yaşar Zorlu3https://orcid.org/0000-0002-4260-0886Ufuk Şener4https://orcid.org/0000-0003-4496-9457Figen Tokuçoğlu5https://orcid.org/0000-0002-7129-948XUniversity of Health Sciences Turkey, Izmir Tepecik Training and Research Hospital, Clinic of Neurology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir Tepecik Training and Research Hospital, Clinic of Neurology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir Tepecik Training and Research Hospital, Clinic of Genetic Diseases, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir Tepecik Training and Research Hospital, Clinic of Neurology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir Tepecik Training and Research Hospital, Clinic of Neurology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir Tepecik Training and Research Hospital, Clinic of Neurology, Izmir, TurkeyObjective: We aimed to determine the association between a polymorphism in the promoter region of the IL-1beta gene resulting in enhanced gene transcription and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Materials and Methods: The frequency of a single nucleotide polymorphism (SNP) that results in a C>T transition of 511 base pairs that are five prime to the transcription start site of the IL-1beta gene in a group of 21 patients with TLE+HS, 21 patients with temporal lobe epilepsy without hippocampal sclerosis (TLE-HS), and 23 healthy volunteers. Results: The frequency of the -511T allele was 11/21 in the TLE-HS group, 13/21 in the TLE+HS group, and 12/23 in the control group. Chi-square analysis of genotype and allele distribution showed no significant difference between the patients in TLE+HS, TLE-HS, and control group Conclusion: There was no association between the -511/C>T SNP variation and TLE+HS.https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-70962&look4=il-1betatemporal lobe epilepsyhippocampal sclerosisepilepsygenetics |
| spellingShingle | Alp Sarıteke İrem Fatma Uludağ Berk Özyılmaz Yaşar Zorlu Ufuk Şener Figen Tokuçoğlu Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis Türk Nöroloji Dergisi il-1beta temporal lobe epilepsy hippocampal sclerosis epilepsy genetics |
| title | Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis |
| title_full | Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis |
| title_fullStr | Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis |
| title_full_unstemmed | Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis |
| title_short | Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis |
| title_sort | association between interleukin 1 beta il 1β gene variation and temporal lobe epilepsy with hippocampal sclerosis |
| topic | il-1beta temporal lobe epilepsy hippocampal sclerosis epilepsy genetics |
| url | https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-70962&look4= |
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