Alteration of gut microbiota in migraine patients with irritable bowel syndrome in a Chinese Han population
ObjectiveMigraine is frequently reported in patients with irritable bowel syndrome (IBS), and emerging evidence suggests that gut microbiota plays a role in migraine and IBS. However, alterations in the gut microbiome in migraine patients with IBS remain unknown. This study aimed to explore the comp...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.899056/full |
| _version_ | 1797988556493291520 |
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| author | Jieqiong Liu Jieqiong Liu Wenjing Tang Lei Hou Jing Wang Rongfei Wang Yaofen Zhang Zhao Dong Ruozhuo Liu Shengyuan Yu |
| author_facet | Jieqiong Liu Jieqiong Liu Wenjing Tang Lei Hou Jing Wang Rongfei Wang Yaofen Zhang Zhao Dong Ruozhuo Liu Shengyuan Yu |
| author_sort | Jieqiong Liu |
| collection | DOAJ |
| description | ObjectiveMigraine is frequently reported in patients with irritable bowel syndrome (IBS), and emerging evidence suggests that gut microbiota plays a role in migraine and IBS. However, alterations in the gut microbiome in migraine patients with IBS remain unknown. This study aimed to explore the compositions of gut microbiota in migraine patients with IBS in a Chinese Han population.MethodsSixteen migraine patients with IBS and thirteen age- and gender-matched IBS patients with similar dietary and lifestyle habits were enrolled in this pilot study. Demographic data, clinical data, eating habits, lifestyle habits, comorbidities, and medications were recorded using a unified case registration form. Questionnaires for the Migraine Disability Assessment (MIDAS), Pittsburgh Sleep Quality Index (PSQI), Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HAMD) were completed. Fecal samples were collected, and microbial DNA was extracted. Gut microbiota 16S ribosomal RNA (16S rRNA) gene sequencing targeting the V4 region was performed using the Illumina HiSeq 2500 high-throughput sequencing platform. The relationships between gut microbiota and clinical characteristics of migraine were analyzed.ResultsThe structure of gut microbiota differed between migraine patients with IBS and patients with IBS, while the richness and diversity of gut microbiota in migraine patients with IBS showed no significant difference from that of patients with IBS. We found a higher relative abundance of the genus Parabacteroides and a lower relative abundance of the genera Paraprevotella, Lachnospiraceae_UCG-010, Lactococcus, Collinsella, and Comamonas in migraine patients with IBS than in patients with IBS. According to random forest predictive models, the phylum Bacteroidota shows the most important role in migraine patients with IBS. Furthermore, no statistical correlation was found between significantly different taxa at the genus level and migraine clinical data.ConclusionThis study identified that altered gut microbiota occurred in Chinese Han migraine patients with IBS, but no correlation was found between gut microbiota and the clinical characteristics of migraine. Further study is needed to better understand the role of gut microbiota in the pathogenesis of migraine in IBS. |
| first_indexed | 2024-04-11T08:04:48Z |
| format | Article |
| id | doaj.art-66f0f9e3ff7f44cd807e8fe3544cc31e |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T08:04:48Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-66f0f9e3ff7f44cd807e8fe3544cc31e2022-12-22T04:35:35ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-11-011310.3389/fneur.2022.899056899056Alteration of gut microbiota in migraine patients with irritable bowel syndrome in a Chinese Han populationJieqiong Liu0Jieqiong Liu1Wenjing Tang2Lei Hou3Jing Wang4Rongfei Wang5Yaofen Zhang6Zhao Dong7Ruozhuo Liu8Shengyuan Yu9Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, ChinaDepartment of Neurology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, ChinaDepartment of Neurology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, ChinaDepartment of Neurology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, ChinaDepartment of Neurology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, ChinaDepartment of Neurology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, ChinaDepartment of Neurology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, ChinaDepartment of Neurology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, ChinaDepartment of Neurology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, ChinaDepartment of Neurology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, ChinaObjectiveMigraine is frequently reported in patients with irritable bowel syndrome (IBS), and emerging evidence suggests that gut microbiota plays a role in migraine and IBS. However, alterations in the gut microbiome in migraine patients with IBS remain unknown. This study aimed to explore the compositions of gut microbiota in migraine patients with IBS in a Chinese Han population.MethodsSixteen migraine patients with IBS and thirteen age- and gender-matched IBS patients with similar dietary and lifestyle habits were enrolled in this pilot study. Demographic data, clinical data, eating habits, lifestyle habits, comorbidities, and medications were recorded using a unified case registration form. Questionnaires for the Migraine Disability Assessment (MIDAS), Pittsburgh Sleep Quality Index (PSQI), Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HAMD) were completed. Fecal samples were collected, and microbial DNA was extracted. Gut microbiota 16S ribosomal RNA (16S rRNA) gene sequencing targeting the V4 region was performed using the Illumina HiSeq 2500 high-throughput sequencing platform. The relationships between gut microbiota and clinical characteristics of migraine were analyzed.ResultsThe structure of gut microbiota differed between migraine patients with IBS and patients with IBS, while the richness and diversity of gut microbiota in migraine patients with IBS showed no significant difference from that of patients with IBS. We found a higher relative abundance of the genus Parabacteroides and a lower relative abundance of the genera Paraprevotella, Lachnospiraceae_UCG-010, Lactococcus, Collinsella, and Comamonas in migraine patients with IBS than in patients with IBS. According to random forest predictive models, the phylum Bacteroidota shows the most important role in migraine patients with IBS. Furthermore, no statistical correlation was found between significantly different taxa at the genus level and migraine clinical data.ConclusionThis study identified that altered gut microbiota occurred in Chinese Han migraine patients with IBS, but no correlation was found between gut microbiota and the clinical characteristics of migraine. Further study is needed to better understand the role of gut microbiota in the pathogenesis of migraine in IBS.https://www.frontiersin.org/articles/10.3389/fneur.2022.899056/fullmigraineirritable bowel syndromegut microbiota16S rRNAgut-brain axis |
| spellingShingle | Jieqiong Liu Jieqiong Liu Wenjing Tang Lei Hou Jing Wang Rongfei Wang Yaofen Zhang Zhao Dong Ruozhuo Liu Shengyuan Yu Alteration of gut microbiota in migraine patients with irritable bowel syndrome in a Chinese Han population Frontiers in Neurology migraine irritable bowel syndrome gut microbiota 16S rRNA gut-brain axis |
| title | Alteration of gut microbiota in migraine patients with irritable bowel syndrome in a Chinese Han population |
| title_full | Alteration of gut microbiota in migraine patients with irritable bowel syndrome in a Chinese Han population |
| title_fullStr | Alteration of gut microbiota in migraine patients with irritable bowel syndrome in a Chinese Han population |
| title_full_unstemmed | Alteration of gut microbiota in migraine patients with irritable bowel syndrome in a Chinese Han population |
| title_short | Alteration of gut microbiota in migraine patients with irritable bowel syndrome in a Chinese Han population |
| title_sort | alteration of gut microbiota in migraine patients with irritable bowel syndrome in a chinese han population |
| topic | migraine irritable bowel syndrome gut microbiota 16S rRNA gut-brain axis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.899056/full |
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