Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset
Background: Few studies have reported the epidemiology and clinical outcome of venous thromboembolism (VTE) in Asian patients with pancreatic cancer. This study investigated the incidence, risk factors, and clinical outcome of VTE in patients with pancreatic cancer following palliative chemotherapy....
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| Format: | Article |
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MDPI AG
2018-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/10/12/501 |
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| author | Jen-Shi Chen Chia-Yen Hung Hung Chang Chien-Ting Liu Yen-Yang Chen Chang-Hsien Lu Pei-Hung Chang Yu-Shin Hung Wen-Chi Chou |
| author_facet | Jen-Shi Chen Chia-Yen Hung Hung Chang Chien-Ting Liu Yen-Yang Chen Chang-Hsien Lu Pei-Hung Chang Yu-Shin Hung Wen-Chi Chou |
| author_sort | Jen-Shi Chen |
| collection | DOAJ |
| description | Background: Few studies have reported the epidemiology and clinical outcome of venous thromboembolism (VTE) in Asian patients with pancreatic cancer. This study investigated the incidence, risk factors, and clinical outcome of VTE in patients with pancreatic cancer following palliative chemotherapy. Methods: The medical records of 838 patients with newly diagnosed locally advanced or metastatic pancreatic cancer who underwent palliative chemotherapy between 2010 and 2016 at four institutes in Taiwan were retrospectively reviewed. The clinical characteristics of all patients were analyzed to identify independent predictors of VTE and their effects on survival outcome. Results: During the median follow-up period of 7.7 months (range, 0.6⁻55.6), VTE occurred in 67 (8.0%) of the 838 patients. Leukocyte count > 11,000/μL and presence of liver metastases were the independent predictors of VTE. Patients with VTE did not show significantly poorer survival outcomes than those without VTE. However, early-onset VTE that occurred within 1.5 months after chemotherapy initiation was an independent negative prognosticator for overall survival. Conclusion: VTE incidence was found to be lower in Asian patients with pancreatic cancer than in their Western counterparts. Early-onset VTE, but not late-onset VTE, is a negative prognosticator for survival outcomes. |
| first_indexed | 2024-03-12T19:53:01Z |
| format | Article |
| id | doaj.art-66f3c36cfc8c454dbb664d362972e597 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:53:01Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-66f3c36cfc8c454dbb664d362972e5972023-08-02T03:00:13ZengMDPI AGCancers2072-66942018-12-01101250110.3390/cancers10120501cancers10120501Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early OnsetJen-Shi Chen0Chia-Yen Hung1Hung Chang2Chien-Ting Liu3Yen-Yang Chen4Chang-Hsien Lu5Pei-Hung Chang6Yu-Shin Hung7Wen-Chi Chou8Departments of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Taoyaun 333, TaiwanDepartments of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Taoyaun 333, TaiwanDepartments of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Taoyaun 333, TaiwanDepartment of Hematology-Oncology, Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung 833, TaiwanDepartment of Hematology-Oncology, Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung 833, TaiwanDepartments of Hematology-Oncology, Chang Gung Memorial Hospital at Chiayi, Chiayi 612, TaiwanDepartment of Hematology-Oncology, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanDepartments of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Taoyaun 333, TaiwanDepartments of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Taoyaun 333, TaiwanBackground: Few studies have reported the epidemiology and clinical outcome of venous thromboembolism (VTE) in Asian patients with pancreatic cancer. This study investigated the incidence, risk factors, and clinical outcome of VTE in patients with pancreatic cancer following palliative chemotherapy. Methods: The medical records of 838 patients with newly diagnosed locally advanced or metastatic pancreatic cancer who underwent palliative chemotherapy between 2010 and 2016 at four institutes in Taiwan were retrospectively reviewed. The clinical characteristics of all patients were analyzed to identify independent predictors of VTE and their effects on survival outcome. Results: During the median follow-up period of 7.7 months (range, 0.6⁻55.6), VTE occurred in 67 (8.0%) of the 838 patients. Leukocyte count > 11,000/μL and presence of liver metastases were the independent predictors of VTE. Patients with VTE did not show significantly poorer survival outcomes than those without VTE. However, early-onset VTE that occurred within 1.5 months after chemotherapy initiation was an independent negative prognosticator for overall survival. Conclusion: VTE incidence was found to be lower in Asian patients with pancreatic cancer than in their Western counterparts. Early-onset VTE, but not late-onset VTE, is a negative prognosticator for survival outcomes.https://www.mdpi.com/2072-6694/10/12/501pancreatic cancervenous thromboembolismincidencepredictoroutcome |
| spellingShingle | Jen-Shi Chen Chia-Yen Hung Hung Chang Chien-Ting Liu Yen-Yang Chen Chang-Hsien Lu Pei-Hung Chang Yu-Shin Hung Wen-Chi Chou Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset Cancers pancreatic cancer venous thromboembolism incidence predictor outcome |
| title | Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset |
| title_full | Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset |
| title_fullStr | Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset |
| title_full_unstemmed | Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset |
| title_short | Venous Thromboembolism in Asian Patients with Pancreatic Cancer Following Palliative Chemotherapy: Low Incidence but a Negative Prognosticator for Those with Early Onset |
| title_sort | venous thromboembolism in asian patients with pancreatic cancer following palliative chemotherapy low incidence but a negative prognosticator for those with early onset |
| topic | pancreatic cancer venous thromboembolism incidence predictor outcome |
| url | https://www.mdpi.com/2072-6694/10/12/501 |
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