In Vivo Reprogramming Using Yamanaka Factors in the CNS: A Scoping Review
Central nervous system diseases, particularly neurodegenerative disorders, pose significant challenges in medicine. These conditions, characterized by progressive neuronal loss, have remained largely incurable, exacting a heavy toll on individuals and society. In recent years, in vivo reprogramming...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/4/343 |
| _version_ | 1797298619185889280 |
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| author | Han Eol Cho Siwoo Lee Jung Hwa Seo Seong-Woong Kang Won Ah Choi Sung-Rae Cho |
| author_facet | Han Eol Cho Siwoo Lee Jung Hwa Seo Seong-Woong Kang Won Ah Choi Sung-Rae Cho |
| author_sort | Han Eol Cho |
| collection | DOAJ |
| description | Central nervous system diseases, particularly neurodegenerative disorders, pose significant challenges in medicine. These conditions, characterized by progressive neuronal loss, have remained largely incurable, exacting a heavy toll on individuals and society. In recent years, in vivo reprogramming using Yamanaka factors has emerged as a promising approach for central nervous system regeneration. This technique involves introducing transcription factors, such as Oct4, Sox2, Klf4, and c-Myc, into adult cells to induce their conversion into neurons. This review summarizes the current state of in vivo reprogramming research in the central nervous system, focusing on the use of Yamanaka factors. In vivo reprogramming using Yamanaka factors has shown promising results in several animal models of central nervous system diseases. Studies have demonstrated that this approach can promote the generation of new neurons, improve functional outcomes, and reduce scar formation. However, there are still several challenges that need to be addressed before this approach can be translated into clinical practice. These challenges include optimizing the efficiency of reprogramming, understanding the cell of origin for each transcription factor, and developing methods for reprogramming in non-subventricular zone areas. Further research is needed to overcome the remaining challenges, but this approach has the potential to revolutionize the way we treat central nervous system disorders. |
| first_indexed | 2024-03-07T22:37:39Z |
| format | Article |
| id | doaj.art-66f640126d7b4f2db923ef5551147f06 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-07T22:37:39Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-66f640126d7b4f2db923ef5551147f062024-02-23T15:11:56ZengMDPI AGCells2073-44092024-02-0113434310.3390/cells13040343In Vivo Reprogramming Using Yamanaka Factors in the CNS: A Scoping ReviewHan Eol Cho0Siwoo Lee1Jung Hwa Seo2Seong-Woong Kang3Won Ah Choi4Sung-Rae Cho5Rehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, Seoul 06229, Republic of KoreaGraduate Program of Biomedical Engineering, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Rehabilitation Medicine, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaRehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, Seoul 06229, Republic of KoreaRehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, Seoul 06229, Republic of KoreaRehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, Seoul 06229, Republic of KoreaCentral nervous system diseases, particularly neurodegenerative disorders, pose significant challenges in medicine. These conditions, characterized by progressive neuronal loss, have remained largely incurable, exacting a heavy toll on individuals and society. In recent years, in vivo reprogramming using Yamanaka factors has emerged as a promising approach for central nervous system regeneration. This technique involves introducing transcription factors, such as Oct4, Sox2, Klf4, and c-Myc, into adult cells to induce their conversion into neurons. This review summarizes the current state of in vivo reprogramming research in the central nervous system, focusing on the use of Yamanaka factors. In vivo reprogramming using Yamanaka factors has shown promising results in several animal models of central nervous system diseases. Studies have demonstrated that this approach can promote the generation of new neurons, improve functional outcomes, and reduce scar formation. However, there are still several challenges that need to be addressed before this approach can be translated into clinical practice. These challenges include optimizing the efficiency of reprogramming, understanding the cell of origin for each transcription factor, and developing methods for reprogramming in non-subventricular zone areas. Further research is needed to overcome the remaining challenges, but this approach has the potential to revolutionize the way we treat central nervous system disorders.https://www.mdpi.com/2073-4409/13/4/343cellular reprogrammingcentral nervous systemYamanaka factorsSRY-box transcription factor 2octamer-binding transcription factor 4 |
| spellingShingle | Han Eol Cho Siwoo Lee Jung Hwa Seo Seong-Woong Kang Won Ah Choi Sung-Rae Cho In Vivo Reprogramming Using Yamanaka Factors in the CNS: A Scoping Review Cells cellular reprogramming central nervous system Yamanaka factors SRY-box transcription factor 2 octamer-binding transcription factor 4 |
| title | In Vivo Reprogramming Using Yamanaka Factors in the CNS: A Scoping Review |
| title_full | In Vivo Reprogramming Using Yamanaka Factors in the CNS: A Scoping Review |
| title_fullStr | In Vivo Reprogramming Using Yamanaka Factors in the CNS: A Scoping Review |
| title_full_unstemmed | In Vivo Reprogramming Using Yamanaka Factors in the CNS: A Scoping Review |
| title_short | In Vivo Reprogramming Using Yamanaka Factors in the CNS: A Scoping Review |
| title_sort | in vivo reprogramming using yamanaka factors in the cns a scoping review |
| topic | cellular reprogramming central nervous system Yamanaka factors SRY-box transcription factor 2 octamer-binding transcription factor 4 |
| url | https://www.mdpi.com/2073-4409/13/4/343 |
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