The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis
Objective: To clarify the relationship between colorectal serrated lesions and serum lipid levels, and provide a scientific basis for the identification and early clinical prevention and treatment of populations that are at risk for colorectal serrated lesions.Methods: Studies comparing serum lipid...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.984586/full |
| _version_ | 1811194629693898752 |
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| author | Xuerui Wang Xuerui Wang Yangbin Zou Ruxuan Zhang Chunyan Teng Xuejiao Ren Haishan Zhang Liting Zhou |
| author_facet | Xuerui Wang Xuerui Wang Yangbin Zou Ruxuan Zhang Chunyan Teng Xuejiao Ren Haishan Zhang Liting Zhou |
| author_sort | Xuerui Wang |
| collection | DOAJ |
| description | Objective: To clarify the relationship between colorectal serrated lesions and serum lipid levels, and provide a scientific basis for the identification and early clinical prevention and treatment of populations that are at risk for colorectal serrated lesions.Methods: Studies comparing serum lipid levels in patients with colorectal serrated lesions and controls were searched in PubMed, Embase, Web of Science, the Cochrane Library, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database. Relevant literature was screened according to the inclusion and exclusion criteria. The mean and standard deviation of the serum lipid levels in patients and controls were extracted from the included literature. The combined weighted mean difference (WMD) and 95% confidence intervals (CIs) were calculated using Review Manager 5.0 software to evaluate the relationship between serum lipid levels and colorectal serrated lesions. Publication bias of the included studies was evaluated by the Egger test.Results: Twenty-three studies were included, comprising 2,063 patients and 63,909 controls. The serum high-density lipoprotein cholesterol (HDL-C) levels in the case group was significantly lower than in the control group (WMD = −0.122 mmol/L, 95% CI: 0.170–0.073). Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and serum triglyceride levels in the case group were significantly higher than in the control group, and the WMDs were 0.180 mmol/L (95% CI: 0.061–0.299), 0.155 mmol/L (95% CI: 0.038–0.273), and 0.241 mmol/L (95% CI: 0.181–0.302), respectively.Conclusion: Colorectal serrated lesions may be related to blood lipid levels. Hyperlipidemia might be a risk factor for colorectal serrated lesions. |
| first_indexed | 2024-04-12T00:29:11Z |
| format | Article |
| id | doaj.art-66f682eedc7141b6b756443defdccd67 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T00:29:11Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-66f682eedc7141b6b756443defdccd672022-12-22T03:55:24ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-10-011310.3389/fphys.2022.984586984586The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysisXuerui Wang0Xuerui Wang1Yangbin Zou2Ruxuan Zhang3Chunyan Teng4Xuejiao Ren5Haishan Zhang6Liting Zhou7Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaDepartment of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, ChinaDepartment of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaObjective: To clarify the relationship between colorectal serrated lesions and serum lipid levels, and provide a scientific basis for the identification and early clinical prevention and treatment of populations that are at risk for colorectal serrated lesions.Methods: Studies comparing serum lipid levels in patients with colorectal serrated lesions and controls were searched in PubMed, Embase, Web of Science, the Cochrane Library, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database. Relevant literature was screened according to the inclusion and exclusion criteria. The mean and standard deviation of the serum lipid levels in patients and controls were extracted from the included literature. The combined weighted mean difference (WMD) and 95% confidence intervals (CIs) were calculated using Review Manager 5.0 software to evaluate the relationship between serum lipid levels and colorectal serrated lesions. Publication bias of the included studies was evaluated by the Egger test.Results: Twenty-three studies were included, comprising 2,063 patients and 63,909 controls. The serum high-density lipoprotein cholesterol (HDL-C) levels in the case group was significantly lower than in the control group (WMD = −0.122 mmol/L, 95% CI: 0.170–0.073). Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and serum triglyceride levels in the case group were significantly higher than in the control group, and the WMDs were 0.180 mmol/L (95% CI: 0.061–0.299), 0.155 mmol/L (95% CI: 0.038–0.273), and 0.241 mmol/L (95% CI: 0.181–0.302), respectively.Conclusion: Colorectal serrated lesions may be related to blood lipid levels. Hyperlipidemia might be a risk factor for colorectal serrated lesions.https://www.frontiersin.org/articles/10.3389/fphys.2022.984586/fullcolorectal polypsessile serrated adenomameta-analysislipidcolorectal serrated lesions |
| spellingShingle | Xuerui Wang Xuerui Wang Yangbin Zou Ruxuan Zhang Chunyan Teng Xuejiao Ren Haishan Zhang Liting Zhou The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis Frontiers in Physiology colorectal polyp sessile serrated adenoma meta-analysis lipid colorectal serrated lesions |
| title | The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis |
| title_full | The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis |
| title_fullStr | The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis |
| title_full_unstemmed | The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis |
| title_short | The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis |
| title_sort | relationship between serum lipid levels and colorectal serrated lesions a systematic review and meta analysis |
| topic | colorectal polyp sessile serrated adenoma meta-analysis lipid colorectal serrated lesions |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.984586/full |
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