Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance
Abstract Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor symptoms in PD, but its relationship with beta acti...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41128-6 |
| _version_ | 1797558585479135232 |
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| author | Zixiao Yin Ruoyu Ma Qi An Yichen Xu Yifei Gan Guanyu Zhu Yin Jiang Ning Zhang Anchao Yang Fangang Meng Andrea A. Kühn Hagai Bergman Wolf-Julian Neumann Jianguo Zhang |
| author_facet | Zixiao Yin Ruoyu Ma Qi An Yichen Xu Yifei Gan Guanyu Zhu Yin Jiang Ning Zhang Anchao Yang Fangang Meng Andrea A. Kühn Hagai Bergman Wolf-Julian Neumann Jianguo Zhang |
| author_sort | Zixiao Yin |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor symptoms in PD, but its relationship with beta activity is unknown. To investigate the clinical potential of beta activity as a biomarker for sleep quality in PD, we recorded pallidal local field potentials during polysomnography in PD patients off dopaminergic medication and compared the results to dystonia patients. PD patients exhibited sustained and elevated beta activity across wakefulness, rapid eye movement (REM), and non-REM sleep, which was correlated with sleep disturbance. Simulation of adaptive stimulation revealed that sleep-related beta activity changes remain unaccounted for by current algorithms, with potential negative outcomes in sleep quality and overall quality of life for patients. |
| first_indexed | 2024-03-10T17:33:36Z |
| format | Article |
| id | doaj.art-66f8bdbea9ea46a59ce1b32c64bcc774 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:33:36Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-66f8bdbea9ea46a59ce1b32c64bcc7742023-11-20T09:55:54ZengNature PortfolioNature Communications2041-17232023-09-0114111210.1038/s41467-023-41128-6Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbanceZixiao Yin0Ruoyu Ma1Qi An2Yichen Xu3Yifei Gan4Guanyu Zhu5Yin Jiang6Ning Zhang7Anchao Yang8Fangang Meng9Andrea A. Kühn10Hagai Bergman11Wolf-Julian Neumann12Jianguo Zhang13Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical UniversityDepartment of Neuropsychiatry, Behavioral Neurology and Sleep Center, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical UniversityDepartment of Neurology, Movement Disorders and Neuromodulation Unit, Charité – Universitätsmedizin BerlinThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew UniversityDepartment of Neurology, Movement Disorders and Neuromodulation Unit, Charité – Universitätsmedizin BerlinDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor symptoms in PD, but its relationship with beta activity is unknown. To investigate the clinical potential of beta activity as a biomarker for sleep quality in PD, we recorded pallidal local field potentials during polysomnography in PD patients off dopaminergic medication and compared the results to dystonia patients. PD patients exhibited sustained and elevated beta activity across wakefulness, rapid eye movement (REM), and non-REM sleep, which was correlated with sleep disturbance. Simulation of adaptive stimulation revealed that sleep-related beta activity changes remain unaccounted for by current algorithms, with potential negative outcomes in sleep quality and overall quality of life for patients.https://doi.org/10.1038/s41467-023-41128-6 |
| spellingShingle | Zixiao Yin Ruoyu Ma Qi An Yichen Xu Yifei Gan Guanyu Zhu Yin Jiang Ning Zhang Anchao Yang Fangang Meng Andrea A. Kühn Hagai Bergman Wolf-Julian Neumann Jianguo Zhang Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance Nature Communications |
| title | Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance |
| title_full | Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance |
| title_fullStr | Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance |
| title_full_unstemmed | Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance |
| title_short | Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance |
| title_sort | pathological pallidal beta activity in parkinson s disease is sustained during sleep and associated with sleep disturbance |
| url | https://doi.org/10.1038/s41467-023-41128-6 |
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