RETRACTED: ECT2 Increases the stability of EGFR and Tumorigenicity by Inhibiting Grb2 Ubiquitination in Pancreatic Cancer

RETRACTED: ECT2 Increases the stability of EGFR and Tumorigenicity by Inhibiting Grb2 Ubiquitination in Pancreatic Cancer

The poor prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is associated with the invasion and metastasis of tumor cells. Epithelial cell transforming 2 (ECT2) is a guanine nucleotide exchange factor (GEF) of the Rho family of GTPases. It has also been reported that upregulation of...

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Bibliographic Details
Main Authors: Junxiong Wang, Shuo Yang, Li Min, Shengtao Zhu, Shuilong Guo, Shutian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
PDAC
ECT2
EGFR
Grb2
EMT
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.589241/full

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