Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?
Antibiotics are often administered with antivenom following snakebite envenomings in order to avoid secondary bacterial infections. However, to this date, no studies have evaluated whether antibiotics may have undesirable potentiating effects on snake venom. Herein, we demonstrate that four commonly...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/12/4/240 |
| _version_ | 1797571125381693440 |
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| author | Christoffer V. Sørensen Cecilie Knudsen Ulrich auf dem auf dem Keller Konstantinos Kalogeropoulos Cristina Gutiérrez-Jiménez Manuela B. Pucca Eliane C. Arantes Karla C. F. Bordon Andreas H. Laustsen |
| author_facet | Christoffer V. Sørensen Cecilie Knudsen Ulrich auf dem auf dem Keller Konstantinos Kalogeropoulos Cristina Gutiérrez-Jiménez Manuela B. Pucca Eliane C. Arantes Karla C. F. Bordon Andreas H. Laustsen |
| author_sort | Christoffer V. Sørensen |
| collection | DOAJ |
| description | Antibiotics are often administered with antivenom following snakebite envenomings in order to avoid secondary bacterial infections. However, to this date, no studies have evaluated whether antibiotics may have undesirable potentiating effects on snake venom. Herein, we demonstrate that four commonly used antibiotics affect the enzymatic activities of proteolytic snake venom toxins in two different in vitro assays. Similar findings in vivo could have clinical implications for snakebite management and require further examination. |
| first_indexed | 2024-03-10T20:34:41Z |
| format | Article |
| id | doaj.art-66fd5242d24c40cd89e3ffb2ae989b2c |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T20:34:41Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-66fd5242d24c40cd89e3ffb2ae989b2c2023-11-19T21:06:37ZengMDPI AGToxins2072-66512020-04-0112424010.3390/toxins12040240Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?Christoffer V. Sørensen0Cecilie Knudsen1Ulrich auf dem auf dem Keller2Konstantinos Kalogeropoulos3Cristina Gutiérrez-Jiménez4Manuela B. Pucca5Eliane C. Arantes6Karla C. F. Bordon7Andreas H. Laustsen8Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, DenmarkDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, DenmarkDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, DenmarkDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, DenmarkDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, DenmarkDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, DenmarkDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto BR-14040-903, BrazilDepartment of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto BR-14040-903, BrazilDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, DenmarkAntibiotics are often administered with antivenom following snakebite envenomings in order to avoid secondary bacterial infections. However, to this date, no studies have evaluated whether antibiotics may have undesirable potentiating effects on snake venom. Herein, we demonstrate that four commonly used antibiotics affect the enzymatic activities of proteolytic snake venom toxins in two different in vitro assays. Similar findings in vivo could have clinical implications for snakebite management and require further examination.https://www.mdpi.com/2072-6651/12/4/240snakebite envenomingvenomantibioticssnake venom serine proteasessnake venom metalloproteasesinfection |
| spellingShingle | Christoffer V. Sørensen Cecilie Knudsen Ulrich auf dem auf dem Keller Konstantinos Kalogeropoulos Cristina Gutiérrez-Jiménez Manuela B. Pucca Eliane C. Arantes Karla C. F. Bordon Andreas H. Laustsen Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms? Toxins snakebite envenoming venom antibiotics snake venom serine proteases snake venom metalloproteases infection |
| title | Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms? |
| title_full | Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms? |
| title_fullStr | Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms? |
| title_full_unstemmed | Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms? |
| title_short | Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms? |
| title_sort | do antibiotics potentiate proteases in hemotoxic snake venoms |
| topic | snakebite envenoming venom antibiotics snake venom serine proteases snake venom metalloproteases infection |
| url | https://www.mdpi.com/2072-6651/12/4/240 |
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