Implantable Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: A Systematic Review of Prospective Studies
Peripheral nerve stimulation (PNS) has been utilized for over 50 years with accumulating evidence of efficacy in a variety of chronic pain conditions. The level and strength of evidence supporting the use of PNS for peripheral neuropathic pain remains unclear. The purpose of this review is to synthe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2606 |
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| author | Steven Char Max Y. Jin Vinicius Tieppo Francio Nasir Hussain Eric J. Wang Mahmoud Morsi Vwaire Orhurhu Larry J. Prokop Adam Fink Ryan S. D’Souza |
| author_facet | Steven Char Max Y. Jin Vinicius Tieppo Francio Nasir Hussain Eric J. Wang Mahmoud Morsi Vwaire Orhurhu Larry J. Prokop Adam Fink Ryan S. D’Souza |
| author_sort | Steven Char |
| collection | DOAJ |
| description | Peripheral nerve stimulation (PNS) has been utilized for over 50 years with accumulating evidence of efficacy in a variety of chronic pain conditions. The level and strength of evidence supporting the use of PNS for peripheral neuropathic pain remains unclear. The purpose of this review is to synthesize data from prospective studies on the efficacy of PNS for neuropathic pain as it pertains to pain intensity, neurological deficits/neuropathy (e.g., weakness, sensory deficits, gait/balance), and other secondary outcomes (quality of life, satisfaction, emotional functioning, and adverse events). In compliance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, this review identified articles from MEDLINE(R), EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus. Overall, per the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria, pooled results demonstrate very low quality or low quality of evidence supporting modest to substantial improvement in pain and neurological function after PNS implantation for treatment of peripheral neuropathic pain. PNS for phantom limb pain was the only indication that had moderate level evidence. Future prospective and well-powered studies are warranted to assess the efficacy of PNS for peripheral neuropathic pain. |
| first_indexed | 2024-03-09T20:37:53Z |
| format | Article |
| id | doaj.art-66ffd7068a69439d83913c5c9d9334ba |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:37:53Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-66ffd7068a69439d83913c5c9d9334ba2023-11-23T23:05:49ZengMDPI AGBiomedicines2227-90592022-10-011010260610.3390/biomedicines10102606Implantable Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: A Systematic Review of Prospective StudiesSteven Char0Max Y. Jin1Vinicius Tieppo Francio2Nasir Hussain3Eric J. Wang4Mahmoud Morsi5Vwaire Orhurhu6Larry J. Prokop7Adam Fink8Ryan S. D’Souza9Department of Anesthesiology & Perioperative Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USADepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Rehabilitation Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Anesthesiology, The Ohio State Wexner Medical Center, Columbus, OH 43210, USADepartment of Anesthesiology and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USADepartment of Anesthesiology & Pain Management, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL 60612, USADepartment of Anesthesiology, University of Pittsburgh Medical Center, Susquehanna, Williamsport, PA 17701, USAMayo Clinic Libraries, Mayo Clinic, Rochester, MN 55902, USA1st Faculty of Medicine, Charles University, 110 00 Prague, Czech RepublicDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic Hospital, Rochester, MN 55902, USAPeripheral nerve stimulation (PNS) has been utilized for over 50 years with accumulating evidence of efficacy in a variety of chronic pain conditions. The level and strength of evidence supporting the use of PNS for peripheral neuropathic pain remains unclear. The purpose of this review is to synthesize data from prospective studies on the efficacy of PNS for neuropathic pain as it pertains to pain intensity, neurological deficits/neuropathy (e.g., weakness, sensory deficits, gait/balance), and other secondary outcomes (quality of life, satisfaction, emotional functioning, and adverse events). In compliance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, this review identified articles from MEDLINE(R), EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus. Overall, per the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria, pooled results demonstrate very low quality or low quality of evidence supporting modest to substantial improvement in pain and neurological function after PNS implantation for treatment of peripheral neuropathic pain. PNS for phantom limb pain was the only indication that had moderate level evidence. Future prospective and well-powered studies are warranted to assess the efficacy of PNS for peripheral neuropathic pain.https://www.mdpi.com/2227-9059/10/10/2606peripheral nerve stimulatorperipheral neuropathychronic painneuromodulation |
| spellingShingle | Steven Char Max Y. Jin Vinicius Tieppo Francio Nasir Hussain Eric J. Wang Mahmoud Morsi Vwaire Orhurhu Larry J. Prokop Adam Fink Ryan S. D’Souza Implantable Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: A Systematic Review of Prospective Studies Biomedicines peripheral nerve stimulator peripheral neuropathy chronic pain neuromodulation |
| title | Implantable Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: A Systematic Review of Prospective Studies |
| title_full | Implantable Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: A Systematic Review of Prospective Studies |
| title_fullStr | Implantable Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: A Systematic Review of Prospective Studies |
| title_full_unstemmed | Implantable Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: A Systematic Review of Prospective Studies |
| title_short | Implantable Peripheral Nerve Stimulation for Peripheral Neuropathic Pain: A Systematic Review of Prospective Studies |
| title_sort | implantable peripheral nerve stimulation for peripheral neuropathic pain a systematic review of prospective studies |
| topic | peripheral nerve stimulator peripheral neuropathy chronic pain neuromodulation |
| url | https://www.mdpi.com/2227-9059/10/10/2606 |
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