Endothelial dysfunction markers in low cardiovascular risk individuals: Comparison of males and females
Background: Cardiovascular diseases (CVD) account for approximately 50% of the total deaths in Turkey. Most of them are related with atherosclerotic coronary heart disease. Predictive value of endothelial dysfunction markers related with the earliest stage of atherosclerosis has been getting more at...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2017-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2017/1452-82581701062G.pdf |
| _version_ | 1798043631927427072 |
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| author | Gungor Zeynep B. Sipahioglu Nurver Sonmez Huseyin Ekmekci Hakan Toprak Sait Ayaz Gulsel Bayram Gurel Cigdem Mutlu Tugba Ulutin Turgut Sipahioglu Fikret Ilerigelen Baris |
| author_facet | Gungor Zeynep B. Sipahioglu Nurver Sonmez Huseyin Ekmekci Hakan Toprak Sait Ayaz Gulsel Bayram Gurel Cigdem Mutlu Tugba Ulutin Turgut Sipahioglu Fikret Ilerigelen Baris |
| author_sort | Gungor Zeynep B. |
| collection | DOAJ |
| description | Background: Cardiovascular diseases (CVD) account for approximately 50% of the total deaths in Turkey. Most of them are related with atherosclerotic coronary heart disease. Predictive value of endothelial dysfunction markers related with the earliest stage of atherosclerosis has been getting more attention. We hypothesized that differences in endothelial dysfunction biochemical markers among genders would aid to capture proatherogenic activity that was not diagnosed by conventional risk assessment scoring systems. Methods: We assessed the endothelial dysfuntion markers in 92 Turkish adults who were in the "low CV risk group" according to ESC (European Society of Cardiology)-Score Risk Charts. We compared the males and females. Results: We observed higher endothelial dysfunction rates in males, with higher median and mean levels of e-NOS, ox-LDL before and after adjustment for HDL lowness and obesity (P = 0 .0 1 8, P = 0.036 for NOS; P = 0 .000 , P= 0.004 for ox-LDL, respectively). Men had higher hsCRP levels than females before adjustment (P = 0.021). Decreased e-NOS levels were related with FMD for females before adjustment for confounders (P = 0 .0 28). We also found significant correlation between e-NOS and ox-LDL levels both before (r= 0.360, P< 0.001) and after adjustment (r= 0.366, P< 0.01) for confounders which pointed out the nitrosative stress. In multivariate regression analyses, after adjusting for other endothelial dysfunction markers which were not included in the ESC-risk scoring system, decreased e-NOS levels were independently asssociated with impaired flow mediated dilatation for females (odds ratio 0.3; P= 0.038). Conclusions: Our results underline the importance of gender in evaluating endothelial dysfunction biochemical markers to assess cardiovascular risk for low CV risk indivuals. |
| first_indexed | 2024-04-11T22:51:47Z |
| format | Article |
| id | doaj.art-67006fba273d4d6895a30b4d69ff2d75 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-04-11T22:51:47Z |
| publishDate | 2017-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-67006fba273d4d6895a30b4d69ff2d752022-12-22T03:58:34ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662017-01-0136162721452-82581701062GEndothelial dysfunction markers in low cardiovascular risk individuals: Comparison of males and femalesGungor Zeynep B.0Sipahioglu Nurver1Sonmez Huseyin2Ekmekci Hakan3Toprak Sait4Ayaz Gulsel5Bayram Gurel Cigdem6Mutlu Tugba7Ulutin Turgut8Sipahioglu Fikret9Ilerigelen Baris10University of Istanbul, Department of Biochemistry, Istanbul, TurkeyUniversity of Istanbul, Department of Family Medicine, Istanbul, TurkeyUniversity of Istanbul, Cerrahpasa Medical School, Department of Biochemistry, Istanbul, TurkeyUniversity of Istanbul, Cerrahpasa Medical School, Department of Biochemistry, Istanbul, TurkeyUniversity of Istanbul, Cerrahpasa Medical School, Department of Biochemistry, Istanbul, TurkeyUniversity of Istanbul, Cerrahpasa Medical School, Department of Medical Biology, Istanbul, TurkeyUniversity of Istanbul, Cerrahpasa Medical School, Department of Medical Biology, Istanbul, TurkeyUniversity of Istanbul, Cerrahpasa Medical School, Department of Medical Biology, Istanbul, TurkeyUniversity of Istanbul, Cerrahpasa Medical School, Department of Medical Biology, Istanbul, TurkeyUniversity of Istanbul, Cerrahpasa Medical School, Department of Internal Medicine, Istanbul, TurkeyUniversity of Istanbul, Cerrahpasa Medical School, Department of Cardiology, Istanbul, TurkeyBackground: Cardiovascular diseases (CVD) account for approximately 50% of the total deaths in Turkey. Most of them are related with atherosclerotic coronary heart disease. Predictive value of endothelial dysfunction markers related with the earliest stage of atherosclerosis has been getting more attention. We hypothesized that differences in endothelial dysfunction biochemical markers among genders would aid to capture proatherogenic activity that was not diagnosed by conventional risk assessment scoring systems. Methods: We assessed the endothelial dysfuntion markers in 92 Turkish adults who were in the "low CV risk group" according to ESC (European Society of Cardiology)-Score Risk Charts. We compared the males and females. Results: We observed higher endothelial dysfunction rates in males, with higher median and mean levels of e-NOS, ox-LDL before and after adjustment for HDL lowness and obesity (P = 0 .0 1 8, P = 0.036 for NOS; P = 0 .000 , P= 0.004 for ox-LDL, respectively). Men had higher hsCRP levels than females before adjustment (P = 0.021). Decreased e-NOS levels were related with FMD for females before adjustment for confounders (P = 0 .0 28). We also found significant correlation between e-NOS and ox-LDL levels both before (r= 0.360, P< 0.001) and after adjustment (r= 0.366, P< 0.01) for confounders which pointed out the nitrosative stress. In multivariate regression analyses, after adjusting for other endothelial dysfunction markers which were not included in the ESC-risk scoring system, decreased e-NOS levels were independently asssociated with impaired flow mediated dilatation for females (odds ratio 0.3; P= 0.038). Conclusions: Our results underline the importance of gender in evaluating endothelial dysfunction biochemical markers to assess cardiovascular risk for low CV risk indivuals.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2017/1452-82581701062G.pdflow cardiovascular (cv) riskendothelial dysfunctionflow mediated dilatation (fmd)genderoxidized ldl (ox-ldl) |
| spellingShingle | Gungor Zeynep B. Sipahioglu Nurver Sonmez Huseyin Ekmekci Hakan Toprak Sait Ayaz Gulsel Bayram Gurel Cigdem Mutlu Tugba Ulutin Turgut Sipahioglu Fikret Ilerigelen Baris Endothelial dysfunction markers in low cardiovascular risk individuals: Comparison of males and females Journal of Medical Biochemistry low cardiovascular (cv) risk endothelial dysfunction flow mediated dilatation (fmd) gender oxidized ldl (ox-ldl) |
| title | Endothelial dysfunction markers in low cardiovascular risk individuals: Comparison of males and females |
| title_full | Endothelial dysfunction markers in low cardiovascular risk individuals: Comparison of males and females |
| title_fullStr | Endothelial dysfunction markers in low cardiovascular risk individuals: Comparison of males and females |
| title_full_unstemmed | Endothelial dysfunction markers in low cardiovascular risk individuals: Comparison of males and females |
| title_short | Endothelial dysfunction markers in low cardiovascular risk individuals: Comparison of males and females |
| title_sort | endothelial dysfunction markers in low cardiovascular risk individuals comparison of males and females |
| topic | low cardiovascular (cv) risk endothelial dysfunction flow mediated dilatation (fmd) gender oxidized ldl (ox-ldl) |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2017/1452-82581701062G.pdf |
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