Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritis
Abstract Background Acute pyelonephritis (APN) with obstructive uropathy often causes sepsis. Recently, sepsis was redefined using the sequential organ failure assessment (SOFA) score, based on the new Sepsis-3 criteria. We investigated predictors for sepsis using this new definition in patients wit...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | BMC Urology |
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| Online Access: | http://link.springer.com/article/10.1186/s12894-020-00596-4 |
| _version_ | 1819208306502139904 |
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| author | Mitsuhiro Tambo Satoru Taguchi Yu Nakamura Takatsugu Okegawa Hiroshi Fukuhara |
| author_facet | Mitsuhiro Tambo Satoru Taguchi Yu Nakamura Takatsugu Okegawa Hiroshi Fukuhara |
| author_sort | Mitsuhiro Tambo |
| collection | DOAJ |
| description | Abstract Background Acute pyelonephritis (APN) with obstructive uropathy often causes sepsis. Recently, sepsis was redefined using the sequential organ failure assessment (SOFA) score, based on the new Sepsis-3 criteria. We investigated predictors for sepsis using this new definition in patients with obstructive APN associated with upper urinary tract calculi. Methods We retrospectively evaluated patients who were admitted to our hospital for treatment of obstructive APN associated with upper urinary tract calculi. Blood and urine samples were collected before treatment of obstructive APN. Treatment included adequate antimicrobial therapy and emergency drainage to decompress the renal collecting system. We diagnosed sepsis using the new Sepsis-3 definition. We assessed predictors for sepsis by multivariate logistic regression analysis. Results Sixty-one patients were included in this study. Overall, all patients underwent emergency drainage, and 11 (18.0%) patients showed sepsis. There were no significant differences in performance status or comorbidities between sepsis and non-sepsis groups. Platelet count and serum albumin level were significantly lower in the sepsis group than in the non-sepsis group (p = 0.001 and p = 0.016, respectively). Procalcitonin (PCT) and presepsin (PSEP) levels were significantly higher in the sepsis group than in the non-sepsis group (p < 0.001 and p < 0.001, respectively). Multivariate analysis showed that PCT elevation (OR = 13.12, p = 0.024) and PSEP elevation (OR = 13.13, p = 0.044) were independent predictors for sepsis. Conclusions Elevation of PCT and PSEP levels before treatment might predict the development of sepsis in patients with obstructive APN. |
| first_indexed | 2024-12-23T05:37:18Z |
| format | Article |
| id | doaj.art-67010e68cc98411c9802c244e1ef54d8 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-12-23T05:37:18Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-67010e68cc98411c9802c244e1ef54d82022-12-21T17:58:17ZengBMCBMC Urology1471-24902020-03-012011710.1186/s12894-020-00596-4Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritisMitsuhiro Tambo0Satoru Taguchi1Yu Nakamura2Takatsugu Okegawa3Hiroshi Fukuhara4Department of Urology, Kyorin University School of MedicineDepartment of Urology, Kyorin University School of MedicineDepartment of Urology, Kyorin University School of MedicineDepartment of Urology, Kyorin University School of MedicineDepartment of Urology, Kyorin University School of MedicineAbstract Background Acute pyelonephritis (APN) with obstructive uropathy often causes sepsis. Recently, sepsis was redefined using the sequential organ failure assessment (SOFA) score, based on the new Sepsis-3 criteria. We investigated predictors for sepsis using this new definition in patients with obstructive APN associated with upper urinary tract calculi. Methods We retrospectively evaluated patients who were admitted to our hospital for treatment of obstructive APN associated with upper urinary tract calculi. Blood and urine samples were collected before treatment of obstructive APN. Treatment included adequate antimicrobial therapy and emergency drainage to decompress the renal collecting system. We diagnosed sepsis using the new Sepsis-3 definition. We assessed predictors for sepsis by multivariate logistic regression analysis. Results Sixty-one patients were included in this study. Overall, all patients underwent emergency drainage, and 11 (18.0%) patients showed sepsis. There were no significant differences in performance status or comorbidities between sepsis and non-sepsis groups. Platelet count and serum albumin level were significantly lower in the sepsis group than in the non-sepsis group (p = 0.001 and p = 0.016, respectively). Procalcitonin (PCT) and presepsin (PSEP) levels were significantly higher in the sepsis group than in the non-sepsis group (p < 0.001 and p < 0.001, respectively). Multivariate analysis showed that PCT elevation (OR = 13.12, p = 0.024) and PSEP elevation (OR = 13.13, p = 0.044) were independent predictors for sepsis. Conclusions Elevation of PCT and PSEP levels before treatment might predict the development of sepsis in patients with obstructive APN.http://link.springer.com/article/10.1186/s12894-020-00596-4Acute pyelonephritisUpper urinary tract calculiSepsisProcalcitoninPresepsin |
| spellingShingle | Mitsuhiro Tambo Satoru Taguchi Yu Nakamura Takatsugu Okegawa Hiroshi Fukuhara Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritis BMC Urology Acute pyelonephritis Upper urinary tract calculi Sepsis Procalcitonin Presepsin |
| title | Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritis |
| title_full | Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritis |
| title_fullStr | Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritis |
| title_full_unstemmed | Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritis |
| title_short | Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritis |
| title_sort | presepsin and procalcitonin as predictors of sepsis based on the new sepsis 3 definitions in obstructive acute pyelonephritis |
| topic | Acute pyelonephritis Upper urinary tract calculi Sepsis Procalcitonin Presepsin |
| url | http://link.springer.com/article/10.1186/s12894-020-00596-4 |
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