Air Pollution: Another Threat to HDL Function
Epidemiological studies have consistently demonstrated a positive association between exposure to air pollutants and the incidence of cardiovascular disease, with the strongest evidence for particles with a diameter < 2.5 μm (PM<sub>2.5</sub>). Therefore, air pollution has been includ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/317 |
| _version_ | 1797625686264905728 |
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| author | Alice Ossoli Federica Cetti Monica Gomaraschi |
| author_facet | Alice Ossoli Federica Cetti Monica Gomaraschi |
| author_sort | Alice Ossoli |
| collection | DOAJ |
| description | Epidemiological studies have consistently demonstrated a positive association between exposure to air pollutants and the incidence of cardiovascular disease, with the strongest evidence for particles with a diameter < 2.5 μm (PM<sub>2.5</sub>). Therefore, air pollution has been included among the modifiable risk factor for cardiovascular outcomes as cardiovascular mortality, acute coronary syndrome, stroke, heart failure, and arrhythmias. Interestingly, the adverse effects of air pollution are more pronounced at higher levels of exposure but were also shown in countries with low levels of air pollution, indicating no apparent safe threshold. It is generally believed that exposure to air pollution in the long-term can accelerate atherosclerosis progression by promoting dyslipidemia, hypertension, and other metabolic disorders due to systemic inflammation and oxidative stress. Regarding high density lipoproteins (HDL), the impact of air pollution on plasma HDL-cholesterol levels is still debated, but there is accumulating evidence that HDL function can be impaired. In particular, the exposure to air pollution has been variably associated with a reduction in their cholesterol efflux capacity, antioxidant and anti-inflammatory potential, and ability to promote the release of nitric oxide. Further studies are needed to fully address the impact of various air pollutants on HDL functions and to elucidate the mechanisms responsible for HDL dysfunction. |
| first_indexed | 2024-03-11T09:59:49Z |
| format | Article |
| id | doaj.art-67018cc4f2c842979231a29c14d2ffad |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:59:49Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-67018cc4f2c842979231a29c14d2ffad2023-11-16T15:31:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124131710.3390/ijms24010317Air Pollution: Another Threat to HDL FunctionAlice Ossoli0Federica Cetti1Monica Gomaraschi2Centro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, ItalyCentro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, ItalyCentro Enrica Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, ItalyEpidemiological studies have consistently demonstrated a positive association between exposure to air pollutants and the incidence of cardiovascular disease, with the strongest evidence for particles with a diameter < 2.5 μm (PM<sub>2.5</sub>). Therefore, air pollution has been included among the modifiable risk factor for cardiovascular outcomes as cardiovascular mortality, acute coronary syndrome, stroke, heart failure, and arrhythmias. Interestingly, the adverse effects of air pollution are more pronounced at higher levels of exposure but were also shown in countries with low levels of air pollution, indicating no apparent safe threshold. It is generally believed that exposure to air pollution in the long-term can accelerate atherosclerosis progression by promoting dyslipidemia, hypertension, and other metabolic disorders due to systemic inflammation and oxidative stress. Regarding high density lipoproteins (HDL), the impact of air pollution on plasma HDL-cholesterol levels is still debated, but there is accumulating evidence that HDL function can be impaired. In particular, the exposure to air pollution has been variably associated with a reduction in their cholesterol efflux capacity, antioxidant and anti-inflammatory potential, and ability to promote the release of nitric oxide. Further studies are needed to fully address the impact of various air pollutants on HDL functions and to elucidate the mechanisms responsible for HDL dysfunction.https://www.mdpi.com/1422-0067/24/1/317high density lipoproteinsair pollutionHDL dysfunctioninflammationoxidative stress |
| spellingShingle | Alice Ossoli Federica Cetti Monica Gomaraschi Air Pollution: Another Threat to HDL Function International Journal of Molecular Sciences high density lipoproteins air pollution HDL dysfunction inflammation oxidative stress |
| title | Air Pollution: Another Threat to HDL Function |
| title_full | Air Pollution: Another Threat to HDL Function |
| title_fullStr | Air Pollution: Another Threat to HDL Function |
| title_full_unstemmed | Air Pollution: Another Threat to HDL Function |
| title_short | Air Pollution: Another Threat to HDL Function |
| title_sort | air pollution another threat to hdl function |
| topic | high density lipoproteins air pollution HDL dysfunction inflammation oxidative stress |
| url | https://www.mdpi.com/1422-0067/24/1/317 |
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