Targeted approaches to delineate neuronal morphology during early development
Understanding the developmental changes that affect neurons is a key step in exploring the assembly and maturation of neural circuits in the brain. For decades, researchers have used a number of labeling techniques to visualize neuronal morphology at different stages of development. However, the eff...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1259360/full |
| _version_ | 1797262513201479680 |
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| author | Bimin Liu Bimin Liu Yuxiao Li Yuxiao Li Miao Ren Miao Ren Xiangning Li Xiangning Li Xiangning Li |
| author_facet | Bimin Liu Bimin Liu Yuxiao Li Yuxiao Li Miao Ren Miao Ren Xiangning Li Xiangning Li Xiangning Li |
| author_sort | Bimin Liu |
| collection | DOAJ |
| description | Understanding the developmental changes that affect neurons is a key step in exploring the assembly and maturation of neural circuits in the brain. For decades, researchers have used a number of labeling techniques to visualize neuronal morphology at different stages of development. However, the efficiency and accuracy of neuronal labeling technologies are limited by the complexity and fragility of neonatal brains. In this review, we illustrate the various labeling techniques utilized for examining the neurogenesis and morphological changes occurring during the early stages of development. We compare the advantages and limitations of each technique from different aspects. Then, we highlight the gaps remaining in our understanding of the structure of neurons in the neonatal mouse brain. |
| first_indexed | 2024-04-24T23:58:18Z |
| format | Article |
| id | doaj.art-670224f7f3194471863febad833c396b |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-24T23:58:18Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-670224f7f3194471863febad833c396b2024-03-14T10:51:11ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-10-011710.3389/fncel.2023.12593601259360Targeted approaches to delineate neuronal morphology during early developmentBimin Liu0Bimin Liu1Yuxiao Li2Yuxiao Li3Miao Ren4Miao Ren5Xiangning Li6Xiangning Li7Xiangning Li8State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou, ChinaKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, ChinaState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou, ChinaKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, ChinaState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou, ChinaKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, ChinaState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou, ChinaKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, ChinaResearch Unit of Multimodal Cross Scale Neural Signal Detection and Imaging, Chinese Academy of Medical Sciences, HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, ChinaUnderstanding the developmental changes that affect neurons is a key step in exploring the assembly and maturation of neural circuits in the brain. For decades, researchers have used a number of labeling techniques to visualize neuronal morphology at different stages of development. However, the efficiency and accuracy of neuronal labeling technologies are limited by the complexity and fragility of neonatal brains. In this review, we illustrate the various labeling techniques utilized for examining the neurogenesis and morphological changes occurring during the early stages of development. We compare the advantages and limitations of each technique from different aspects. Then, we highlight the gaps remaining in our understanding of the structure of neurons in the neonatal mouse brain.https://www.frontiersin.org/articles/10.3389/fncel.2023.1259360/fullneonatal miceneural labelingmorphologyneural circuitdevelopment |
| spellingShingle | Bimin Liu Bimin Liu Yuxiao Li Yuxiao Li Miao Ren Miao Ren Xiangning Li Xiangning Li Xiangning Li Targeted approaches to delineate neuronal morphology during early development Frontiers in Cellular Neuroscience neonatal mice neural labeling morphology neural circuit development |
| title | Targeted approaches to delineate neuronal morphology during early development |
| title_full | Targeted approaches to delineate neuronal morphology during early development |
| title_fullStr | Targeted approaches to delineate neuronal morphology during early development |
| title_full_unstemmed | Targeted approaches to delineate neuronal morphology during early development |
| title_short | Targeted approaches to delineate neuronal morphology during early development |
| title_sort | targeted approaches to delineate neuronal morphology during early development |
| topic | neonatal mice neural labeling morphology neural circuit development |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1259360/full |
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