More than skin deep: cyclic peptides as wound healing and cytoprotective compounds
The prevalence and cost of wounds pose a challenge to patients as well as the healthcare system. Wounds can involve multiple tissue types and, in some cases, become chronic and difficult to treat. Comorbidities may also decrease the rate of tissue regeneration and complicate healing. Currently, trea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1195600/full |
| _version_ | 1797814276818206720 |
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| author | Ying-Chiang J. Lee Bahar Javdan Alexis Cowan Keith Smith |
| author_facet | Ying-Chiang J. Lee Bahar Javdan Alexis Cowan Keith Smith |
| author_sort | Ying-Chiang J. Lee |
| collection | DOAJ |
| description | The prevalence and cost of wounds pose a challenge to patients as well as the healthcare system. Wounds can involve multiple tissue types and, in some cases, become chronic and difficult to treat. Comorbidities may also decrease the rate of tissue regeneration and complicate healing. Currently, treatment relies on optimizing healing factors rather than administering effective targeted therapies. Owing to their enormous diversity in structure and function, peptides are among the most prevalent and biologically important class of compounds and have been investigated for their wound healing bioactivities. A class of these peptides, called cyclic peptides, confer stability and improved pharmacokinetics, and are an ideal source of wound healing therapeutics. This review provides an overview of cyclic peptides that have been shown to promote wound healing in various tissues and in model organisms. In addition, we describe cytoprotective cyclic peptides that mitigate ischemic reperfusion injuries. Advantages and challenges in harnessing the healing potential for cyclic peptides from a clinical perspective are also discussed. Cyclic peptides are a potentially attractive category of wound healing compounds and more research in this field could not only rely on design as mimetics but also encompass de novo approaches as well. |
| first_indexed | 2024-03-13T08:05:14Z |
| format | Article |
| id | doaj.art-6708817aa8be40c7a43161207eb5d53a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-13T08:05:14Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6708817aa8be40c7a43161207eb5d53a2023-06-01T05:15:33ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-06-011110.3389/fcell.2023.11956001195600More than skin deep: cyclic peptides as wound healing and cytoprotective compoundsYing-Chiang J. Lee0Bahar Javdan1Alexis Cowan2Keith Smith3Department of Molecular Biology, Princeton University, Princeton, NJ, United StatesRutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United StatesDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesMerck & Co., Inc., Kenilworth, NJ, United StatesThe prevalence and cost of wounds pose a challenge to patients as well as the healthcare system. Wounds can involve multiple tissue types and, in some cases, become chronic and difficult to treat. Comorbidities may also decrease the rate of tissue regeneration and complicate healing. Currently, treatment relies on optimizing healing factors rather than administering effective targeted therapies. Owing to their enormous diversity in structure and function, peptides are among the most prevalent and biologically important class of compounds and have been investigated for their wound healing bioactivities. A class of these peptides, called cyclic peptides, confer stability and improved pharmacokinetics, and are an ideal source of wound healing therapeutics. This review provides an overview of cyclic peptides that have been shown to promote wound healing in various tissues and in model organisms. In addition, we describe cytoprotective cyclic peptides that mitigate ischemic reperfusion injuries. Advantages and challenges in harnessing the healing potential for cyclic peptides from a clinical perspective are also discussed. Cyclic peptides are a potentially attractive category of wound healing compounds and more research in this field could not only rely on design as mimetics but also encompass de novo approaches as well.https://www.frontiersin.org/articles/10.3389/fcell.2023.1195600/fullcyclic peptidewound healingbioactivityregenerationskinbone |
| spellingShingle | Ying-Chiang J. Lee Bahar Javdan Alexis Cowan Keith Smith More than skin deep: cyclic peptides as wound healing and cytoprotective compounds Frontiers in Cell and Developmental Biology cyclic peptide wound healing bioactivity regeneration skin bone |
| title | More than skin deep: cyclic peptides as wound healing and cytoprotective compounds |
| title_full | More than skin deep: cyclic peptides as wound healing and cytoprotective compounds |
| title_fullStr | More than skin deep: cyclic peptides as wound healing and cytoprotective compounds |
| title_full_unstemmed | More than skin deep: cyclic peptides as wound healing and cytoprotective compounds |
| title_short | More than skin deep: cyclic peptides as wound healing and cytoprotective compounds |
| title_sort | more than skin deep cyclic peptides as wound healing and cytoprotective compounds |
| topic | cyclic peptide wound healing bioactivity regeneration skin bone |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1195600/full |
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