Continuum theory of gene expression waves during vertebrate segmentation
The segmentation of the vertebrate body plan during embryonic development is a rhythmic and sequential process governed by genetic oscillations. These genetic oscillations give rise to traveling waves of gene expression in the segmenting tissue. Here we present a minimal continuum theory of vertebra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2015-01-01
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| Series: | New Journal of Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/1367-2630/17/9/093042 |
| _version_ | 1797751031009902592 |
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| author | David J Jörg Luis G Morelli Daniele Soroldoni Andrew C Oates Frank Jülicher |
| author_facet | David J Jörg Luis G Morelli Daniele Soroldoni Andrew C Oates Frank Jülicher |
| author_sort | David J Jörg |
| collection | DOAJ |
| description | The segmentation of the vertebrate body plan during embryonic development is a rhythmic and sequential process governed by genetic oscillations. These genetic oscillations give rise to traveling waves of gene expression in the segmenting tissue. Here we present a minimal continuum theory of vertebrate segmentation that captures the key principles governing the dynamic patterns of gene expression including the effects of shortening of the oscillating tissue. We show that our theory can quantitatively account for the key features of segmentation observed in zebrafish, in particular the shape of the wave patterns, the period of segmentation and the segment length as a function of time. |
| first_indexed | 2024-03-12T16:42:28Z |
| format | Article |
| id | doaj.art-670a4c73309d4f7a96f1b30781763b47 |
| institution | Directory Open Access Journal |
| issn | 1367-2630 |
| language | English |
| last_indexed | 2024-03-12T16:42:28Z |
| publishDate | 2015-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | New Journal of Physics |
| spelling | doaj.art-670a4c73309d4f7a96f1b30781763b472023-08-08T14:24:02ZengIOP PublishingNew Journal of Physics1367-26302015-01-0117909304210.1088/1367-2630/17/9/093042Continuum theory of gene expression waves during vertebrate segmentationDavid J Jörg0Luis G Morelli1Daniele Soroldoni2Andrew C Oates3Frank Jülicher4Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, D-01187 Dresden, GermanyDepartamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina; IFIBA, CONICET, Pabellón 1, Ciudad Universitaria, 1428 Buenos Aires, ArgentinaFrancis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK; Max Planck Institute for Cell Biology and Genetics, Pfotenhauerstr. 108, D-01307 Dresden, GermanyFrancis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UKMax Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, D-01187 Dresden, GermanyThe segmentation of the vertebrate body plan during embryonic development is a rhythmic and sequential process governed by genetic oscillations. These genetic oscillations give rise to traveling waves of gene expression in the segmenting tissue. Here we present a minimal continuum theory of vertebrate segmentation that captures the key principles governing the dynamic patterns of gene expression including the effects of shortening of the oscillating tissue. We show that our theory can quantitatively account for the key features of segmentation observed in zebrafish, in particular the shape of the wave patterns, the period of segmentation and the segment length as a function of time.https://doi.org/10.1088/1367-2630/17/9/093042coupled oscillatorsmorphogenesispattern formation05.45.Xt82.39.Rt87.17.Pq |
| spellingShingle | David J Jörg Luis G Morelli Daniele Soroldoni Andrew C Oates Frank Jülicher Continuum theory of gene expression waves during vertebrate segmentation New Journal of Physics coupled oscillators morphogenesis pattern formation 05.45.Xt 82.39.Rt 87.17.Pq |
| title | Continuum theory of gene expression waves during vertebrate segmentation |
| title_full | Continuum theory of gene expression waves during vertebrate segmentation |
| title_fullStr | Continuum theory of gene expression waves during vertebrate segmentation |
| title_full_unstemmed | Continuum theory of gene expression waves during vertebrate segmentation |
| title_short | Continuum theory of gene expression waves during vertebrate segmentation |
| title_sort | continuum theory of gene expression waves during vertebrate segmentation |
| topic | coupled oscillators morphogenesis pattern formation 05.45.Xt 82.39.Rt 87.17.Pq |
| url | https://doi.org/10.1088/1367-2630/17/9/093042 |
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