Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers
<p>Abstract</p> <p>Calcium phosphate is the most important inorganic constituent of biological tissues, and synthetic calcium phosphate has been widely used as biomaterials. In this study, a facile method has been developed for the fabrication of amorphous calcium phosphate (ACP)/p...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2011-01-01
|
| Series: | Nanoscale Research Letters |
| Online Access: | http://www.nanoscalereslett.com/content/6/1/67 |
| _version_ | 1797758772982054912 |
|---|---|
| author | Zhang Kui-Hua Mo Xiu-Mei Chen Feng Zhu Ying-Jie Wu Jin Wang Ke-Wei Tang Qi-Li |
| author_facet | Zhang Kui-Hua Mo Xiu-Mei Chen Feng Zhu Ying-Jie Wu Jin Wang Ke-Wei Tang Qi-Li |
| author_sort | Zhang Kui-Hua |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Calcium phosphate is the most important inorganic constituent of biological tissues, and synthetic calcium phosphate has been widely used as biomaterials. In this study, a facile method has been developed for the fabrication of amorphous calcium phosphate (ACP)/polylactide-block-monomethoxy(polyethyleneglycol) hybrid nanoparticles and ACP porous nanospheres. Europium-doping is performed to enable photoluminescence (PL) function of ACP porous nanospheres. A high specific surface area of the europium-doped ACP (Eu<sup>3+</sup>:ACP) porous nanospheres is achieved (126.7 m<sup>2</sup>/g). PL properties of Eu<sup>3+</sup>:ACP porous nanospheres are investigated, and the most intense peak at 612 nm is observed at 5 mol% Eu<sup>3+ </sup>doping. <it>In vitro </it>cytotoxicity experiments indicate that the as-prepared Eu<sup>3+</sup>:ACP porous nanospheres are biocompatible. <it>In vitro </it>drug release experiments indicate that the ibuprofen-loaded Eu<sup>3+</sup>:ACP porous nanospheres show a slow and sustained drug release in simulated body fluid. We have found that the cumulative amount of released drug has a linear relationship with the natural logarithm of release time (<it>ln</it>(<it>t</it>)). The Eu<sup>3+</sup>:ACP porous nanospheres are bioactive, and can transform to hydroxyapatite during drug release. The PL properties of drug-loaded nanocarriers before and after drug release are also investigated.</p> |
| first_indexed | 2024-03-12T18:34:57Z |
| format | Article |
| id | doaj.art-670b066cc19548f9b710e4420ca349e4 |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T18:34:57Z |
| publishDate | 2011-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-670b066cc19548f9b710e4420ca349e42023-08-02T08:04:13ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2011-01-016167Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriersZhang Kui-HuaMo Xiu-MeiChen FengZhu Ying-JieWu JinWang Ke-WeiTang Qi-Li<p>Abstract</p> <p>Calcium phosphate is the most important inorganic constituent of biological tissues, and synthetic calcium phosphate has been widely used as biomaterials. In this study, a facile method has been developed for the fabrication of amorphous calcium phosphate (ACP)/polylactide-block-monomethoxy(polyethyleneglycol) hybrid nanoparticles and ACP porous nanospheres. Europium-doping is performed to enable photoluminescence (PL) function of ACP porous nanospheres. A high specific surface area of the europium-doped ACP (Eu<sup>3+</sup>:ACP) porous nanospheres is achieved (126.7 m<sup>2</sup>/g). PL properties of Eu<sup>3+</sup>:ACP porous nanospheres are investigated, and the most intense peak at 612 nm is observed at 5 mol% Eu<sup>3+ </sup>doping. <it>In vitro </it>cytotoxicity experiments indicate that the as-prepared Eu<sup>3+</sup>:ACP porous nanospheres are biocompatible. <it>In vitro </it>drug release experiments indicate that the ibuprofen-loaded Eu<sup>3+</sup>:ACP porous nanospheres show a slow and sustained drug release in simulated body fluid. We have found that the cumulative amount of released drug has a linear relationship with the natural logarithm of release time (<it>ln</it>(<it>t</it>)). The Eu<sup>3+</sup>:ACP porous nanospheres are bioactive, and can transform to hydroxyapatite during drug release. The PL properties of drug-loaded nanocarriers before and after drug release are also investigated.</p>http://www.nanoscalereslett.com/content/6/1/67 |
| spellingShingle | Zhang Kui-Hua Mo Xiu-Mei Chen Feng Zhu Ying-Jie Wu Jin Wang Ke-Wei Tang Qi-Li Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers Nanoscale Research Letters |
| title | Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers |
| title_full | Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers |
| title_fullStr | Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers |
| title_full_unstemmed | Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers |
| title_short | Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers |
| title_sort | europium doped amorphous calcium phosphate porous nanospheres preparation and application as luminescent drug carriers |
| url | http://www.nanoscalereslett.com/content/6/1/67 |
| work_keys_str_mv | AT zhangkuihua europiumdopedamorphouscalciumphosphateporousnanospherespreparationandapplicationasluminescentdrugcarriers AT moxiumei europiumdopedamorphouscalciumphosphateporousnanospherespreparationandapplicationasluminescentdrugcarriers AT chenfeng europiumdopedamorphouscalciumphosphateporousnanospherespreparationandapplicationasluminescentdrugcarriers AT zhuyingjie europiumdopedamorphouscalciumphosphateporousnanospherespreparationandapplicationasluminescentdrugcarriers AT wujin europiumdopedamorphouscalciumphosphateporousnanospherespreparationandapplicationasluminescentdrugcarriers AT wangkewei europiumdopedamorphouscalciumphosphateporousnanospherespreparationandapplicationasluminescentdrugcarriers AT tangqili europiumdopedamorphouscalciumphosphateporousnanospherespreparationandapplicationasluminescentdrugcarriers |