Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer
Abstract Background Selection of the best lymph node for dissection is a controversial topic in clinical stage-I non-small cell lung cancer (NSCLC). Here, we sought to identify the clinicopathologic predictors of regional lymph node metastasis in patients intraoperatively diagnosed with stage-I NSCL...
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| Language: | English |
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BMC
2019-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-019-5632-2 |
| _version_ | 1818851278093025280 |
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| author | Fei Zhao Fu-Xi Zhen Yue Zhou Chen-Jun Huang Yue Yu Jun Li Qi-Fan Li Cheng-Xiang Zhu Xiao-Yu Yang Shu-Hui You Qian-Ge Wu Xue-Yun Qin Yi Liu Liang Chen Wei Wang |
| author_facet | Fei Zhao Fu-Xi Zhen Yue Zhou Chen-Jun Huang Yue Yu Jun Li Qi-Fan Li Cheng-Xiang Zhu Xiao-Yu Yang Shu-Hui You Qian-Ge Wu Xue-Yun Qin Yi Liu Liang Chen Wei Wang |
| author_sort | Fei Zhao |
| collection | DOAJ |
| description | Abstract Background Selection of the best lymph node for dissection is a controversial topic in clinical stage-I non-small cell lung cancer (NSCLC). Here, we sought to identify the clinicopathologic predictors of regional lymph node metastasis in patients intraoperatively diagnosed with stage-I NSCLC. Methods A retrospective review of 595 patients intraoperatively diagnosed as stage I non-small-cell lung cancer who underwent lobectomy with complete lymph node dissection was performed. Univariate and multivariable logistic regression analysis was performed to determine the independent predictors of regional lymph node metastasis. Results Univariate logistic regression and multivariable analysis revealed three independent predictors of the presence of metastatic hilar lymph nodes, five independent predictors for lobe specific mediastinal lymph nodes, two independent predictors for lobe nonspecific mediastinal lymph nodes and two independent predictors for skipping mediastinal lymph nodes. Conclusions A complete mediastinal lymph node dissection may be considered for patients suspected of nerve invasion and albumin (> 43.1 g/L) or nerve and vascular invasions. Lobe-specific lymph node dissection should probably be performed for patients suspected of pulmonary membrane invasion, vascular invasion, CEA (> 2.21 ng/mL), and tumor (> 1.6 cm) in the right lower lobe or mixed lobes. Hilar lymph node dissection should probably be performed for patients suspected of having bronchial mucosa and cartilage invasion, vascular invasion, and CEA (> 2.21 ng/mL). |
| first_indexed | 2024-12-19T07:02:29Z |
| format | Article |
| id | doaj.art-670c18b207ee4755871a648f4e9884db |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-19T07:02:29Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-670c18b207ee4755871a648f4e9884db2022-12-21T20:31:22ZengBMCBMC Cancer1471-24072019-05-0119111210.1186/s12885-019-5632-2Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancerFei Zhao0Fu-Xi Zhen1Yue Zhou2Chen-Jun Huang3Yue Yu4Jun Li5Qi-Fan Li6Cheng-Xiang Zhu7Xiao-Yu Yang8Shu-Hui You9Qian-Ge Wu10Xue-Yun Qin11Yi Liu12Liang Chen13Wei Wang14Department of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical UniversityAbstract Background Selection of the best lymph node for dissection is a controversial topic in clinical stage-I non-small cell lung cancer (NSCLC). Here, we sought to identify the clinicopathologic predictors of regional lymph node metastasis in patients intraoperatively diagnosed with stage-I NSCLC. Methods A retrospective review of 595 patients intraoperatively diagnosed as stage I non-small-cell lung cancer who underwent lobectomy with complete lymph node dissection was performed. Univariate and multivariable logistic regression analysis was performed to determine the independent predictors of regional lymph node metastasis. Results Univariate logistic regression and multivariable analysis revealed three independent predictors of the presence of metastatic hilar lymph nodes, five independent predictors for lobe specific mediastinal lymph nodes, two independent predictors for lobe nonspecific mediastinal lymph nodes and two independent predictors for skipping mediastinal lymph nodes. Conclusions A complete mediastinal lymph node dissection may be considered for patients suspected of nerve invasion and albumin (> 43.1 g/L) or nerve and vascular invasions. Lobe-specific lymph node dissection should probably be performed for patients suspected of pulmonary membrane invasion, vascular invasion, CEA (> 2.21 ng/mL), and tumor (> 1.6 cm) in the right lower lobe or mixed lobes. Hilar lymph node dissection should probably be performed for patients suspected of having bronchial mucosa and cartilage invasion, vascular invasion, and CEA (> 2.21 ng/mL).http://link.springer.com/article/10.1186/s12885-019-5632-2Non-small cell lung cancerRegional lymph nodeMetastasisMultivariable logistic regression |
| spellingShingle | Fei Zhao Fu-Xi Zhen Yue Zhou Chen-Jun Huang Yue Yu Jun Li Qi-Fan Li Cheng-Xiang Zhu Xiao-Yu Yang Shu-Hui You Qian-Ge Wu Xue-Yun Qin Yi Liu Liang Chen Wei Wang Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer BMC Cancer Non-small cell lung cancer Regional lymph node Metastasis Multivariable logistic regression |
| title | Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer |
| title_full | Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer |
| title_fullStr | Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer |
| title_full_unstemmed | Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer |
| title_short | Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer |
| title_sort | clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage i non small cell lung cancer |
| topic | Non-small cell lung cancer Regional lymph node Metastasis Multivariable logistic regression |
| url | http://link.springer.com/article/10.1186/s12885-019-5632-2 |
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