Nevus-associated Lentigo Maligna and Lentigo Maligna Melanoma, Clinicopathological Features
Nevus-associated lentigo maligna and lentigo maligna melanoma (NALMM) are rarely described in the literature and are considered an incidental finding. This study aimed to evaluate the frequency of NALMM and its clinicopathological features. A total of 201 histopathology reports were reviewed and amo...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2024-04-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/18381 |
| _version_ | 1797202460058583040 |
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| author | Iara R.T. Drakensjö Mari-Anne Hedblad Eugenia Colón Cervantes Ada Girnita |
| author_facet | Iara R.T. Drakensjö Mari-Anne Hedblad Eugenia Colón Cervantes Ada Girnita |
| author_sort | Iara R.T. Drakensjö |
| collection | DOAJ |
| description | Nevus-associated lentigo maligna and lentigo maligna melanoma (NALMM) are rarely described in the literature and are considered an incidental finding. This study aimed to evaluate the frequency of NALMM and its clinicopathological features. A total of 201 histopathology reports were reviewed and among them 20% of the samples corresponded to NALMM, with females overrepresented in this group (p = 0.02). A significant association was also observed between NALMM with the presence of multiple nevi (p = 0.01), and dysplastic nevi (p = 0.04). Moreover, the risk of developing a second melanoma of nevus-associated type was 4.3 times higher in patients with NALMM. These results indicate that NALMM is more frequent than previously reported, suggesting that the associated nevus could interact or even act as a precursor for LM/LMM. Future studies with larger samples allied to techniques like confocal microscopy and molecular analysis are essential to determine this biological link between nevus and LM/LMM.
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| first_indexed | 2024-04-24T08:03:47Z |
| format | Article |
| id | doaj.art-670c4a6397e14b869c732339cacb644d |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-04-24T08:03:47Z |
| publishDate | 2024-04-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-670c4a6397e14b869c732339cacb644d2024-04-17T12:49:52ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572024-04-0110410.2340/actadv.v104.18381Nevus-associated Lentigo Maligna and Lentigo Maligna Melanoma, Clinicopathological FeaturesIara R.T. Drakensjö0Mari-Anne Hedblad1Eugenia Colón Cervantes2Ada GirnitaSkin Cancer Center, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical and Surgical Pathology, Unilabs, Stockholm, SwedenDepartment of Clinical and Surgical Pathology, Unilabs, Stockholm, SwedenDepartment of Clinical and Surgical Pathology, Unilabs, Stockholm, SwedenNevus-associated lentigo maligna and lentigo maligna melanoma (NALMM) are rarely described in the literature and are considered an incidental finding. This study aimed to evaluate the frequency of NALMM and its clinicopathological features. A total of 201 histopathology reports were reviewed and among them 20% of the samples corresponded to NALMM, with females overrepresented in this group (p = 0.02). A significant association was also observed between NALMM with the presence of multiple nevi (p = 0.01), and dysplastic nevi (p = 0.04). Moreover, the risk of developing a second melanoma of nevus-associated type was 4.3 times higher in patients with NALMM. These results indicate that NALMM is more frequent than previously reported, suggesting that the associated nevus could interact or even act as a precursor for LM/LMM. Future studies with larger samples allied to techniques like confocal microscopy and molecular analysis are essential to determine this biological link between nevus and LM/LMM. https://medicaljournalssweden.se/actadv/article/view/18381De novo melanomaLentigo maligna melanomaNeviNevus associated melanoma |
| spellingShingle | Iara R.T. Drakensjö Mari-Anne Hedblad Eugenia Colón Cervantes Ada Girnita Nevus-associated Lentigo Maligna and Lentigo Maligna Melanoma, Clinicopathological Features Acta Dermato-Venereologica De novo melanoma Lentigo maligna melanoma Nevi Nevus associated melanoma |
| title | Nevus-associated Lentigo Maligna and Lentigo Maligna Melanoma, Clinicopathological Features |
| title_full | Nevus-associated Lentigo Maligna and Lentigo Maligna Melanoma, Clinicopathological Features |
| title_fullStr | Nevus-associated Lentigo Maligna and Lentigo Maligna Melanoma, Clinicopathological Features |
| title_full_unstemmed | Nevus-associated Lentigo Maligna and Lentigo Maligna Melanoma, Clinicopathological Features |
| title_short | Nevus-associated Lentigo Maligna and Lentigo Maligna Melanoma, Clinicopathological Features |
| title_sort | nevus associated lentigo maligna and lentigo maligna melanoma clinicopathological features |
| topic | De novo melanoma Lentigo maligna melanoma Nevi Nevus associated melanoma |
| url | https://medicaljournalssweden.se/actadv/article/view/18381 |
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