Preventive effects of sea cucumber (Apostichopus japonicus) ethanol extract on palmitate-induced vascular injury in vivo
Cardiovascular diseases (CVDs) have posed serious public health problems, accounting for nearly 30% of mortality worldwide and their incidence is still increasing. Therefore, new treatment resources are necessary to prevent or manage the ev...
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| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Fisheries and Aquatic Science
2022-02-01
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| Series: | Fisheries and Aquatic Sciences |
| Subjects: | |
| Online Access: | http://www.e-fas.org/archive/view_article?pid=fas-25-2-90 |
| _version_ | 1819003228263546880 |
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| author | Chunying Zhang Seon-Heui Cha |
| author_facet | Chunying Zhang Seon-Heui Cha |
| author_sort | Chunying Zhang |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) have posed serious public health problems,
accounting for nearly 30% of mortality worldwide and their incidence is
still increasing. Therefore, new treatment resources are necessary to prevent or
manage the ever-increasing population of patients with CVDs. Sea cucumber is
well known for its medical and health benefit effects, but it is not well known
what/how effect it has on vascular disease. In the present study, we examined
the protect effect of sea cucumber, Apostichopus japonicus
80% ethanol extract (AJE) on zebrafish embryo with the stimulation of
free fatty acid, palmitate (PA). In vivo study showed that AJE
can attenuate PA-induced toxicity through relieving the rapid heartbeat,
increasing the survival rate and reducing the malformation in both wild type and
Tg (flila:eGFP) transgenic zebrafish lines. Additionally,
compare with PA treated embryos, the yolk sac area, body length, axial vascular
segment (AVS) and intersegmental vessel (ISV) of the co-treatment group of AJE
and PA were comparable to the control group. Moreover, AJE lowered the
expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO) and
inflammation-related genes induced by PA, and inhibited PA-induced vascular
development disorders. Our data preliminarily verify that AJE could be a
candidate resource for the prevention or therapy of CVDs. |
| first_indexed | 2024-12-20T23:17:40Z |
| format | Article |
| id | doaj.art-670d637c78b24900ba9b5c20dd3df1ca |
| institution | Directory Open Access Journal |
| issn | 2234-1757 |
| language | English |
| last_indexed | 2024-12-20T23:17:40Z |
| publishDate | 2022-02-01 |
| publisher | The Korean Society of Fisheries and Aquatic Science |
| record_format | Article |
| series | Fisheries and Aquatic Sciences |
| spelling | doaj.art-670d637c78b24900ba9b5c20dd3df1ca2022-12-21T19:23:36ZengThe Korean Society of Fisheries and Aquatic ScienceFisheries and Aquatic Sciences2234-17572022-02-012529010010.47853/FAS.2022.e9fas-25-2-90Preventive effects of sea cucumber (Apostichopus japonicus) ethanol extract on palmitate-induced vascular injury in vivoChunying Zhang0Seon-Heui Cha1Department of Marine Bio and Medical Sciences, Hanseo University, Department of Marine Bio and Medical Sciences, Hanseo University, Cardiovascular diseases (CVDs) have posed serious public health problems, accounting for nearly 30% of mortality worldwide and their incidence is still increasing. Therefore, new treatment resources are necessary to prevent or manage the ever-increasing population of patients with CVDs. Sea cucumber is well known for its medical and health benefit effects, but it is not well known what/how effect it has on vascular disease. In the present study, we examined the protect effect of sea cucumber, Apostichopus japonicus 80% ethanol extract (AJE) on zebrafish embryo with the stimulation of free fatty acid, palmitate (PA). In vivo study showed that AJE can attenuate PA-induced toxicity through relieving the rapid heartbeat, increasing the survival rate and reducing the malformation in both wild type and Tg (flila:eGFP) transgenic zebrafish lines. Additionally, compare with PA treated embryos, the yolk sac area, body length, axial vascular segment (AVS) and intersegmental vessel (ISV) of the co-treatment group of AJE and PA were comparable to the control group. Moreover, AJE lowered the expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO) and inflammation-related genes induced by PA, and inhibited PA-induced vascular development disorders. Our data preliminarily verify that AJE could be a candidate resource for the prevention or therapy of CVDs.http://www.e-fas.org/archive/view_article?pid=fas-25-2-90apostichopus japonicusmarine natural productpalmitatevascularinflammation |
| spellingShingle | Chunying Zhang Seon-Heui Cha Preventive effects of sea cucumber (Apostichopus japonicus) ethanol extract on palmitate-induced vascular injury in vivo Fisheries and Aquatic Sciences apostichopus japonicus marine natural product palmitate vascular inflammation |
| title | Preventive effects of sea cucumber (Apostichopus
japonicus) ethanol extract on palmitate-induced vascular injury
in vivo |
| title_full | Preventive effects of sea cucumber (Apostichopus
japonicus) ethanol extract on palmitate-induced vascular injury
in vivo |
| title_fullStr | Preventive effects of sea cucumber (Apostichopus
japonicus) ethanol extract on palmitate-induced vascular injury
in vivo |
| title_full_unstemmed | Preventive effects of sea cucumber (Apostichopus
japonicus) ethanol extract on palmitate-induced vascular injury
in vivo |
| title_short | Preventive effects of sea cucumber (Apostichopus
japonicus) ethanol extract on palmitate-induced vascular injury
in vivo |
| title_sort | preventive effects of sea cucumber apostichopus japonicus ethanol extract on palmitate induced vascular injury in vivo |
| topic | apostichopus japonicus marine natural product palmitate vascular inflammation |
| url | http://www.e-fas.org/archive/view_article?pid=fas-25-2-90 |
| work_keys_str_mv | AT chunyingzhang preventiveeffectsofseacucumberapostichopusjaponicusethanolextractonpalmitateinducedvascularinjuryinvivo AT seonheuicha preventiveeffectsofseacucumberapostichopusjaponicusethanolextractonpalmitateinducedvascularinjuryinvivo |