Promoter Methylation Leads to Decreased ZFP36 Expression and Deregulated NLRP3 Inflammasome Activation in Psoriatic Fibroblasts

Promoter Methylation Leads to Decreased ZFP36 Expression and Deregulated NLRP3 Inflammasome Activation in Psoriatic Fibroblasts

The mRNA-destabilizing protein tristetraprolin (TTP), encoded by the ZFP36 gene, is known to be able to end inflammatory responses by directly targeting and destabilizing mRNAs encoding pro-inflammatory cytokines. We analyzed its role in psoriasis, a disease characterized by chronic inflammation. We...

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Bibliographic Details
Main Authors: Matteo Bertesi, Sebastian Fantini, Claudia Alecci, Roberta Lotti, Andrea Martello, Sandra Parenti, Chiara Carretta, Alessandra Marconi, Alexis Grande, Carlo Pincelli, Tommaso Zanocco-Marani
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Medicine
Subjects:
psoriasis
inflammasome
methylation
ZFP36
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.579383/full

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