Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience
Background: Selenium has an anti-diabetic action as it an insulin-mimetic and antioxidant nutrient. Selenoprotein P (SeP) is an extracellular glycoprotein, that was linked to insulin resistance (IR). Aim: To validate of serum SeP as a measure for insulin resistance in patients with type 1 diabetes...
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| Format: | Article |
| Language: | English |
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Cairo University, Faculty of Medicine, Department of Pediatrics
2022-01-01
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| Series: | Pediatric Sciences Journal |
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| Online Access: | https://cupsj.journals.ekb.eg/article_210817_6154945413a3fbb41f5f250878c93483.pdf |
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| author | Hend Mehawed Soliman Balsam Sherif Fahmy Selim Mohamed Abdelkader Samah A. Hassanein |
| author_facet | Hend Mehawed Soliman Balsam Sherif Fahmy Selim Mohamed Abdelkader Samah A. Hassanein |
| author_sort | Hend Mehawed Soliman |
| collection | DOAJ |
| description | Background: Selenium has an anti-diabetic action as it an insulin-mimetic and antioxidant nutrient. Selenoprotein P (SeP) is an extracellular glycoprotein, that was linked to insulin resistance (IR).
Aim: To validate of serum SeP as a measure for insulin resistance in patients with type 1 diabetes mellitus (T1DM).
Methods: This prospective case-control study included 45 children and adolescents with T1DM and 45 healthy children and adolescents. Serum SeP was measured by ELISA and compared to estimated glucose disposal rate (eGDR) as a measure of insulin resistance.
Results: Mean ± SD of SeP level was higher in T1DM patients than control group (59.78 ± 59.38 ng/ml, 55.57 ± 7.6 ng/ml,respectively), this difference was statistically insignificant (p= 0.642). SeP demonstrated significant positive correlations with duration of diabetes (r=0.413, p=0.005), high density lipoproteins (r=0.496, p=0.001) and glycosylated hemoglobin (r=0.357, p=0.016). There were statistically significant differences in eGDR between cases and controls (7.78±3.08 mg/kg/min, 12.53±0.91mg/kg/min, respectively, (p= 0.001). There was no correlation between SeP level and eGDR values (IR indicator).
Conclusion: Serum SeP level in T1DM patients was not indicative of IR. Higher serum SeP level are associated with longer duration and poor control of T1DM. |
| first_indexed | 2024-03-13T01:59:21Z |
| format | Article |
| id | doaj.art-670ee23da4a145a59bcc6e567a3b49d7 |
| institution | Directory Open Access Journal |
| issn | 2805-279X 2682-3985 |
| language | English |
| last_indexed | 2024-03-13T01:59:21Z |
| publishDate | 2022-01-01 |
| publisher | Cairo University, Faculty of Medicine, Department of Pediatrics |
| record_format | Article |
| series | Pediatric Sciences Journal |
| spelling | doaj.art-670ee23da4a145a59bcc6e567a3b49d72023-07-02T04:24:14ZengCairo University, Faculty of Medicine, Department of PediatricsPediatric Sciences Journal2805-279X2682-39852022-01-0121323810.21608/cupsj.2021.108303.1040Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center ExperienceHend Mehawed Soliman0Balsam Sherif Fahmy1Selim Mohamed Abdelkader2Samah A. Hassanein3https://orcid.org/0000-0002-9745-6770Pediatrics Department, Faculty of Medicine, Cairo University, EgyptClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, EgyptPediatrics Department, El Menshawy General Hospital, Tanta, EgyptPediatrics Department, Faculty of Medicine, Cairo University, EgyptBackground: Selenium has an anti-diabetic action as it an insulin-mimetic and antioxidant nutrient. Selenoprotein P (SeP) is an extracellular glycoprotein, that was linked to insulin resistance (IR). Aim: To validate of serum SeP as a measure for insulin resistance in patients with type 1 diabetes mellitus (T1DM). Methods: This prospective case-control study included 45 children and adolescents with T1DM and 45 healthy children and adolescents. Serum SeP was measured by ELISA and compared to estimated glucose disposal rate (eGDR) as a measure of insulin resistance. Results: Mean ± SD of SeP level was higher in T1DM patients than control group (59.78 ± 59.38 ng/ml, 55.57 ± 7.6 ng/ml,respectively), this difference was statistically insignificant (p= 0.642). SeP demonstrated significant positive correlations with duration of diabetes (r=0.413, p=0.005), high density lipoproteins (r=0.496, p=0.001) and glycosylated hemoglobin (r=0.357, p=0.016). There were statistically significant differences in eGDR between cases and controls (7.78±3.08 mg/kg/min, 12.53±0.91mg/kg/min, respectively, (p= 0.001). There was no correlation between SeP level and eGDR values (IR indicator). Conclusion: Serum SeP level in T1DM patients was not indicative of IR. Higher serum SeP level are associated with longer duration and poor control of T1DM.https://cupsj.journals.ekb.eg/article_210817_6154945413a3fbb41f5f250878c93483.pdfdiabetes mellitusinsulin resistanceselenoprotein pestimated glucose disposal rate. |
| spellingShingle | Hend Mehawed Soliman Balsam Sherif Fahmy Selim Mohamed Abdelkader Samah A. Hassanein Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience Pediatric Sciences Journal diabetes mellitus insulin resistance selenoprotein p estimated glucose disposal rate. |
| title | Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience |
| title_full | Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience |
| title_fullStr | Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience |
| title_full_unstemmed | Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience |
| title_short | Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience |
| title_sort | serum selenoprotein p level is not indicative of insulin resistance in children and adolescents with type 1 diabetes mellitus single center experience |
| topic | diabetes mellitus insulin resistance selenoprotein p estimated glucose disposal rate. |
| url | https://cupsj.journals.ekb.eg/article_210817_6154945413a3fbb41f5f250878c93483.pdf |
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