Allograft Reaction After Latanoprost use Following Penetrating Keratoplasty for Corneal Scarring due to Herpetic Keratitis
A 27-year-old male patient with a corneal scar secondary to herpetic keratitis in the right eye underwent penetrating keratoplasty (PK). At the 14th month of follow-up, latanoprost was started to treat high intraocular pressure which was refractory to treatment. On the 15th day of latanoprost use,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2012-03-01
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| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.oftalmoloji.org/article_2145/Allograft-Reaction-After-Latanoprost-Use-Following-Penetrating-Keratoplasty-For-Corneal-Scarring-Due-To-Herpetic-Keratitis |
| _version_ | 1797924256941604864 |
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| author | Tahir Kansu Bozkurt Ayşe Ebru Bahadır Selda Aktay Kutan Suphi Acar |
| author_facet | Tahir Kansu Bozkurt Ayşe Ebru Bahadır Selda Aktay Kutan Suphi Acar |
| author_sort | Tahir Kansu Bozkurt |
| collection | DOAJ |
| description | A 27-year-old male patient with a corneal scar secondary to herpetic keratitis in the right eye underwent penetrating keratoplasty (PK).
At the 14th month of follow-up, latanoprost was started to treat high intraocular pressure which was refractory to treatment. On the 15th
day of latanoprost use, allograft reaction (AR) developed. Insufficient clinical response despite intensive immunosuppressive therapy made
us consider the possibility of recurrent herpetic keratouveitis secondary to steroid treatment. The dramatic reduction in the number of
keratic precipitates with oral valacyclovir treatment confirmed this diagnosis. The graft remained clear 3 months after the AR treatment.
Inflammation in eyes that had undergone PK jeopardizes the graft success by disrupting the immune privilege of anterior chamber.
Considering the effects of prostaglandin analogues on blood-aqueous barrier, latanoprost use might have been related to allograft reaction
in this case. Another remarkable characteristics of this case was the herpes simplex virus (HSV) reactivation secondary to AR therapy. For
this reason, oral acyclovir prophylaxis together with AR therapy would improve graft success in cases with HSV history. (Turk J
Oph thal mol 2012; 42: 150-3) |
| first_indexed | 2024-04-10T14:58:45Z |
| format | Article |
| id | doaj.art-670f65079e1941859a3c366ede8a7aee |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T14:58:45Z |
| publishDate | 2012-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-670f65079e1941859a3c366ede8a7aee2023-02-15T16:07:11ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612012-03-0142215015310.4274/tjo.42.462200Allograft Reaction After Latanoprost use Following Penetrating Keratoplasty for Corneal Scarring due to Herpetic KeratitisTahir Kansu Bozkurt0Ayşe Ebru Bahadır1Selda Aktay Kutan2Suphi Acar3Gümüşsuyu Asker Hastanesi, Göz Kliniği, İstanbul, TürkiyeSakarya Hendek Devlet Hastanesi, Göz Kliniği, Sakarya, TürkiyeKaradeniz Ereğli Devlet Hastanesi, Göz Kliniği, Zonguldak, TürkiyeHaydarpaşa Numune Eğitim ve Araştırma Hastanesi, 2. Göz Kliniği, Istanbul, TürkiyeA 27-year-old male patient with a corneal scar secondary to herpetic keratitis in the right eye underwent penetrating keratoplasty (PK). At the 14th month of follow-up, latanoprost was started to treat high intraocular pressure which was refractory to treatment. On the 15th day of latanoprost use, allograft reaction (AR) developed. Insufficient clinical response despite intensive immunosuppressive therapy made us consider the possibility of recurrent herpetic keratouveitis secondary to steroid treatment. The dramatic reduction in the number of keratic precipitates with oral valacyclovir treatment confirmed this diagnosis. The graft remained clear 3 months after the AR treatment. Inflammation in eyes that had undergone PK jeopardizes the graft success by disrupting the immune privilege of anterior chamber. Considering the effects of prostaglandin analogues on blood-aqueous barrier, latanoprost use might have been related to allograft reaction in this case. Another remarkable characteristics of this case was the herpes simplex virus (HSV) reactivation secondary to AR therapy. For this reason, oral acyclovir prophylaxis together with AR therapy would improve graft success in cases with HSV history. (Turk J Oph thal mol 2012; 42: 150-3)http://www.oftalmoloji.org/article_2145/Allograft-Reaction-After-Latanoprost-Use-Following-Penetrating-Keratoplasty-For-Corneal-Scarring-Due-To-Herpetic-Keratitis: Allograft reactionherpes simplex viruslatanoprostoral acylovir prophylaxispenetrating keratoplasty |
| spellingShingle | Tahir Kansu Bozkurt Ayşe Ebru Bahadır Selda Aktay Kutan Suphi Acar Allograft Reaction After Latanoprost use Following Penetrating Keratoplasty for Corneal Scarring due to Herpetic Keratitis Türk Oftalmoloji Dergisi : Allograft reaction herpes simplex virus latanoprost oral acylovir prophylaxis penetrating keratoplasty |
| title | Allograft Reaction After Latanoprost use Following Penetrating Keratoplasty for Corneal Scarring due to Herpetic Keratitis |
| title_full | Allograft Reaction After Latanoprost use Following Penetrating Keratoplasty for Corneal Scarring due to Herpetic Keratitis |
| title_fullStr | Allograft Reaction After Latanoprost use Following Penetrating Keratoplasty for Corneal Scarring due to Herpetic Keratitis |
| title_full_unstemmed | Allograft Reaction After Latanoprost use Following Penetrating Keratoplasty for Corneal Scarring due to Herpetic Keratitis |
| title_short | Allograft Reaction After Latanoprost use Following Penetrating Keratoplasty for Corneal Scarring due to Herpetic Keratitis |
| title_sort | allograft reaction after latanoprost use following penetrating keratoplasty for corneal scarring due to herpetic keratitis |
| topic | : Allograft reaction herpes simplex virus latanoprost oral acylovir prophylaxis penetrating keratoplasty |
| url | http://www.oftalmoloji.org/article_2145/Allograft-Reaction-After-Latanoprost-Use-Following-Penetrating-Keratoplasty-For-Corneal-Scarring-Due-To-Herpetic-Keratitis |
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