Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD

Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD

Abstract Background Although ɑ-synuclein (ɑ-syn) spreading in age-related neurodegenerative diseases such as Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB) has been extensively investigated, the role of aging in the manifestation of disease remains unclear. Methods We explored the role...

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Bibliographic Details
Main Authors: Michiyo Iba, Ross A. McDevitt, Changyoun Kim, Roshni Roy, Dimitra Sarantopoulou, Ella Tommer, Byron Siegars, Michelle Sallin, Somin Kwon, Jyoti Misra Sen, Ranjan Sen, Eliezer Masliah
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Molecular Neurodegeneration
Subjects:
ɑ-synuclein
Aging
Parkinson’s disease
Dementia with Lewy bodies
Preformed fibrils
Inflammation
Online Access:https://doi.org/10.1186/s13024-022-00564-6

Internet

https://doi.org/10.1186/s13024-022-00564-6

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