Effects of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) in Recurrent Spontaneous Abortion (RSA)
Recurrent Spontaneous Abortion (RSA) is the most painful experience for couples expecting a child. This study aimed to determine the relevance of IL-2 and IL-6 in recurrent spontaneous abortion (RSA). Serum samples were collected from 90 women attend Al Kadhmiya teaching hospital in Baghdad. 60 wom...
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2017-03-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/569 |
| _version_ | 1818821292597444608 |
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| author | Dhamraa w. Ahmed |
| author_facet | Dhamraa w. Ahmed |
| author_sort | Dhamraa w. Ahmed |
| collection | DOAJ |
| description | Recurrent Spontaneous Abortion (RSA) is the most painful experience for couples expecting a child. This study aimed to determine the relevance of IL-2 and IL-6 in recurrent spontaneous abortion (RSA). Serum samples were collected from 90 women attend Al Kadhmiya teaching hospital in Baghdad. 60 women (first group) had recurrent abortion the women were negative for rubella virus, herpes simplex virus and toxplasma gondii. And they were negative from bacterial infection eg. Niesseria gonorrhea and Chlamydia trachomatis. The histopathological tests for fetus abnormalities were negative in this group, and 30 women (second group) with successful pregnancy (normal delivery). All samples were analyzed for IL-2 and IL-6 by commercially available Enzyme-Linked Immunosorbent Assay (ELISA) kits. The data showed highly significant increase in the serum level of IL-2 in group 1 compared with group 2 (P<0.001). However, IL-6 showed highly significant increase level in group 2 compared with group 1. In addition, there was no significant correlation between these two markers in studied groups. The data of this study strengthen the possibility that high level of IL-2 and low level of IL-6 may explain the role of type-1 cytokines in the pathogenicity of recurrent spontaneous abortion.
Key words: - interleukin 2, interleukin 6 and recurrent spontaneous abortion (RSA) |
| first_indexed | 2024-12-18T23:05:52Z |
| format | Article |
| id | doaj.art-671012363a9f486ab02461aca9f6b7e4 |
| institution | Directory Open Access Journal |
| issn | 2521-3512 1683-3597 |
| language | English |
| last_indexed | 2024-12-18T23:05:52Z |
| publishDate | 2017-03-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-671012363a9f486ab02461aca9f6b7e42022-12-21T20:48:25ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972017-03-0117210.31351/vol17iss2pp74-79Effects of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) in Recurrent Spontaneous Abortion (RSA)Dhamraa w. AhmedRecurrent Spontaneous Abortion (RSA) is the most painful experience for couples expecting a child. This study aimed to determine the relevance of IL-2 and IL-6 in recurrent spontaneous abortion (RSA). Serum samples were collected from 90 women attend Al Kadhmiya teaching hospital in Baghdad. 60 women (first group) had recurrent abortion the women were negative for rubella virus, herpes simplex virus and toxplasma gondii. And they were negative from bacterial infection eg. Niesseria gonorrhea and Chlamydia trachomatis. The histopathological tests for fetus abnormalities were negative in this group, and 30 women (second group) with successful pregnancy (normal delivery). All samples were analyzed for IL-2 and IL-6 by commercially available Enzyme-Linked Immunosorbent Assay (ELISA) kits. The data showed highly significant increase in the serum level of IL-2 in group 1 compared with group 2 (P<0.001). However, IL-6 showed highly significant increase level in group 2 compared with group 1. In addition, there was no significant correlation between these two markers in studied groups. The data of this study strengthen the possibility that high level of IL-2 and low level of IL-6 may explain the role of type-1 cytokines in the pathogenicity of recurrent spontaneous abortion. Key words: - interleukin 2, interleukin 6 and recurrent spontaneous abortion (RSA)https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/569 |
| spellingShingle | Dhamraa w. Ahmed Effects of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) in Recurrent Spontaneous Abortion (RSA) Iraqi Journal of Pharmaceutical Sciences |
| title | Effects of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) in Recurrent Spontaneous Abortion (RSA) |
| title_full | Effects of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) in Recurrent Spontaneous Abortion (RSA) |
| title_fullStr | Effects of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) in Recurrent Spontaneous Abortion (RSA) |
| title_full_unstemmed | Effects of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) in Recurrent Spontaneous Abortion (RSA) |
| title_short | Effects of Interleukin-2 (IL-2) and Interleukin-6 (IL-6) in Recurrent Spontaneous Abortion (RSA) |
| title_sort | effects of interleukin 2 il 2 and interleukin 6 il 6 in recurrent spontaneous abortion rsa |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/569 |
| work_keys_str_mv | AT dhamraawahmed effectsofinterleukin2il2andinterleukin6il6inrecurrentspontaneousabortionrsa |